Latest Hybridization probe Stories

University of Illinois at Urbana-Champaign Miniaturized laboratory-on-chip systems promise rapid, sensitive, and multiplexed detection of biological samples for medical diagnostics, drug discovery, and high-throughput screening. Using micro-fabrication techniques and incorporating a unique design of transistor-based heating, researchers at the University of Illinois at Urbana-Champaign are further advancing the use of silicon transistor and electronics into chemistry and biology for...

In April 2009, the world took notice as reports surfaced of a virus in Mexico that had mutated from pigs and was being passed from human to human. The H1N1 "swine flu," as the virus was named, circulated worldwide, killing more than 18,000 people, according to the World Health Organization. The Centers for Disease Control and Prevention in the United States said it was the first global pandemic in more than four decades. Swine flu will not be the last viral mutation to cause a worldwide...

Using a pair of exotic techniques including a molecular-scale version of ice fishing, a team of researchers working at the National Institute of Standards and Technology (NIST) have developed methods to measure accurately the length of "nanopores," the miniscule channels found in cell membranes. The "molecular rulers" they describe in a recent paper* could serve as a way to calibrate tailor-made nanopores"”whose diameters on average are nearly 10,000 times smaller than...

By Nikiforova, Marina N; Hsi, Eric D; Braziel, Rita M; Gulley, Margaret L; Et al * Context.-The diagnosis of B-cell lymphoid malignancy can frequently be substantiated by detecting clonal immunoglobulin heavy chain (IGH ) gene rearrangements, which is typically done by polymerase chain reaction (PCR) amplification and/or Southern blot analysis. Objective.-To characterize current laboratory practice for the assessment of IGH rearrangements and to identify opportunities for improvement....