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Last updated on April 17, 2014 at 1:21 EDT

Latest Hyperammonemia Stories

2013-12-04 04:21:23

BLAINVILLE, QC, Dec. 4, 2013 /PRNewswire/ - Medunik Canada, a pharmaceutical company specialized in orphan drugs and Lucane Pharma, a French niche pharmaceutical company, announced the conclusion of an exclusive collaboration agreement. Through this agreement, Medunik Canada receives the exclusive Canadian rights to market and distribute a new therapeutic option for patients suffering from Urea Cycle Disorders (UCD), a group of rare diseases involving deficiencies of...

2013-11-18 20:40:35

A study out today in the journal Nature Medicine suggests a potential new treatment for the seizures that often plague children with genetic metabolic disorders and individuals undergoing liver failure. The discovery hinges on a new understanding of the complex molecular chain reaction that occurs when the brain is exposed to too much ammonia. The study shows that elevated levels of ammonia in the blood overwhelm the brain’s defenses, ultimately causing nerve cells to become overexcited....

2012-11-08 08:34:56

SAN DIEGO, Nov. 8, 2012 /PRNewswire/ -- Ocera Therapeutics, Inc. announced that the first patient has enrolled in a Phase 2a study to evaluate the safety and tolerability of OCR-002 (ornithine phenylacetate) in the treatment of patients with acute liver injury (ALI) as well as those that have progressed to acute liver failure (ALF) following acetaminophen overdose. OCR-002 is an investigational drug designed to directly reduce circulating blood levels of ammonia which, at high levels, is...

2012-07-05 02:23:53

BLAINVILLE, QC, July 5, 2012 /PRNewswire/ - Medunik Canada, is an orphan drug company dedicated to helping Canadians with rare diseases access therapies currently unavailable in Canada. Medunik Canada is proud to announce that it has signed an exclusive distribution agreement with Orphan Europe Recordati Group. Under this agreement, Medunik Canada receives the exclusive Canadian rights to market and distribute four important therapies in the following medical conditions: (1) acute...

2012-05-29 02:26:48

BARCELONA, Spain and SAN DIEGO, May 29, 2012 /PRNewswire/ --- Hospital Universitari Vall d'Hebron Research Institute in Barcelona and Ocera Therapeutics, Inc. announced today preliminary data from an open label phase 2 study evaluating the overall effectiveness and safety of OCR-002 (ornithine phenylacetate) for the treatment of cirrhosis of the liver and upper GI bleeding. An interim analysis of the first cohort of patients demonstrated that OCR-002 is well tolerated and provided a rapid and...

2011-12-13 09:58:00

WEINHEIM, Germany, Dec. 13, 2011 /PRNewswire/ -- For the first time in the Midwest, a baby with urea cycle disorder (UCD) has received an investigational liver cell therapy as part of a clinical trial sponsored by international biotechnology firm Cytonet. The liver cell transplantation performed at Children's Memorial Hospital in Chicago is the second of its kind in the United States. UCDs are congenital and often life-threatening disorders of ammonia metabolism in the liver. Neurotoxic...

2011-10-19 06:52:00

WEINHEIM, Germany, Oct. 19, 2011 /PRNewswire/ -- The Canadian health authority, Health Canada, recently granted Cytonet approval to extend the SELICA III trial, which has been open in the United States since 2010, into Canada. The clinical trial is designed to evaluate the safety and efficacy of liver cell therapy in infants to children up to age 5 with urea cycle disorders (UCD). Two centers in Canada join the 12 medical centers in the United States taking part in the trial: the Alberta...

2011-05-17 13:32:00

WEINHEIM, Germany, May 17, 2011 /PRNewswire/ -- International biotechnology firm Cytonet, which is investigating a liver cell infusion of donated human liver cells for the treatment of urea cycle disorders (UCD) in young children, announced it has been granted orphan drug designation by the U.S. Food and Drug Administration (FDA). "This designation recognizes our work to advance the landscape of UCD treatment for young children and offer a much-needed new option for a very serious...

2011-04-26 00:00:27

Children's Memorial Hospital in Chicago is one of only 12 sites across the United States enrolling patients in a national clinical research trial which, for the first time is the United States, is using an investigational liver cell infusion to treat urea cycle disorders (UCDs) in children. UCDs are congenital and often life-threatening disorders of ammonia metabolism in the liver. Neurotoxic ammonia accumulates in the body, which may lead "“ depending on the severity of the disease...

2011-04-14 14:48:00

WEINHEIM, Germany, April 14, 2011 /PRNewswire/ -- International biotechnology firm Cytonet recently launched the first ever clinical trial in the United States using an investigational liver cell infusion to treat urea cycle disorders (UCD) in children. The first patient in the Phase II trial, which will seek to enroll 20 patients in 12 medical centers, is a child with citrullinemia, which is a hereditary UCD. He received six liver cell infusions on six consecutive days at Yale School of...