Latest Hypothalamus Stories

A recent UT Southwestern Medical Center study found that estrogen regulates energy expenditure, appetite and body weight, while insufficient estrogen receptors in specific parts of the brain may lead to obesity. "Estrogen has a profound effect on metabolism," said Dr. Deborah Clegg, associate professor of internal medicine and senior author of the study published Oct. 5 in Cell Metabolism. "We hadn't previously thought of sex hormones as being critical regulators of food intake and body...

It's no secret that women often gain weight as they get older. The sex hormone estrogen has an important, if underappreciated, role to play in those burgeoning waistlines. Now, researchers reporting in the October Cell Metabolism, a Cell Press publication, have traced those hormonal effects on metabolism to different parts of the brain. The findings may lead to the development of highly selective hormone replacement therapies that could be used to combat obesity or infertility in women...

Scientists have discovered a biological switch that gives energy-storing white fat the characteristics of energy-burning brown fat. The findings could lead to new strategies for treating obesity. The animal study by researchers at The Ohio State University Medical Center shows that the change is due to the activation of a nerve and biochemical pathway that begins in the hypothalamus, an area of the brain involved in energy balance, and ends in white fat cells. This pathway, called the...

Obesity is growing at alarming rates worldwide, and the biggest culprit is overeating. In a study of brain circuits that control hunger and satiety, Yale School of Medicine researchers have found that molecular mechanisms controlling free radicals—molecules tied to aging and tissue damage—are at the heart of increased appetite in diet-induced obesity. Published Aug. 28 in the advanced online issue of Nature Medicine, the study found that elevating free radical levels in the...

Thomas Jefferson University research reveals hormone receptor GCC’s role in appetite and possible therapeutic target for obesity The hormone receptor guanylyl cyclase C (GCC) has been established as a suppressor of colorectal cancer tumors, but new evidence from Thomas Jefferson University suggests it may also help fight one of the country's biggest pandemics: obesity. Reporting in the August 25 online issue of the Journal of Clinical Investigation, Scott Waldman, M.D., Ph.D.,...

The number of people who are obese and suffer one or more of its associated health problems (including type 2 diabetes) is escalating dramatically. Researchers are seeking to identify new targets for therapeutics that could limit appetite and thereby obesity. A team of researchers, led by Scott Waldman, at Thomas Jefferson University, Philadelphia, has now uncovered one such potential target by studying the molecular control of appetite in mice. In the study, Waldman and colleagues found...

Researchers in the Hotchkiss Brain Institute (HBI) at the University of Calgary's Faculty of Medicine have uncovered a mechanism by which stress increases food drive in rats. This new discovery, published online this week in the journal Neuron, could provide important insight into why stress is thought to be one of the underlying contributors to obesity.Normally, the brain produces neurotransmitters (chemicals responsible for how cells communicate in the brain) called endocannabinoids that...

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The past two decades have witnessed an epidemic spread of obesity-related diseases in Western countries. Elucidating the biological mechanism that links overnutrition to obesity could prove crucial in reducing obesity levels. In the July 26 issue of PLoS Biology, Dr. Dongsheng Cai and his research team at Albert Einstein College of Medicine describe a pathway that directs the brain to sense the body's glucose dynamics, and they find that a defect of this glucose sensing process contributes to...

(Ivanhoe Newswire) -- The past two decades have witnessed an epidemic spread of obesity-related diseases in Western countries. Elucidating the biological mechanism that links overnutrition to obesity could prove crucial in reducing obesity levels. Researchers found a pathway that directs the brain to sense the body's glucose dynamics, and they believe that a defect of this glucose-sensing pathway contributes to the development of obesity. The correction of this defect can normalize the whole...