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Last updated on April 18, 2014 at 21:21 EDT

Latest Iain Cheeseman Stories

2012-02-13 13:16:03

To solve a mystery, sometimes a great detective need only study the clues in front of him. Like Agatha Christie's Hercule Poirot and Arthur Conan Doyle's Sherlock Holmes, Tomomi Kiyomitsu used his keen powers of observation to solve a puzzle that had mystified researchers for years: in a cell undergoing mitotic cell division, what internal signals cause its chromosomes to align on a center axis? "People have been looking at these proteins and players in mitosis for decades, and no one ever...

2011-04-28 21:19:59

FINDINGS: Whitehead Institute scientists report that two proteins once thought to have only supporting roles, are the true "stars" of the kinetochore assembly process in human cells. RELEVANCE: The kinetochore is vital to proper DNA distribution during cell division. This finding suggests that scientists may be able to stimulate kinetochore assembly in a process that could lead to new genetic research tools, such as efficient creation of artificial human chromosomes. Widespread use of...

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2010-10-15 08:16:31

Unless you are in a field of study related to cell biology, you most likely have never heard of Ndc80. Yet this protein complex is essential to mitosis, the process by which a living cell separates its chromosomes and distributes them equally between its two daughter cells. Now, through a combination of cryo-electron microscopy and three-dimensional image reconstruction, a team of researchers with the Lawrence Berkeley National Laboratory (Berkeley Lab) and the University of California (UC)...

2010-05-14 10:16:25

Whitehead Institute researchers have determined a key part of how cells regulate the chromosome/microtubule interface, which is central to proper chromosomal distribution during cell division. "This is the surveillance machinery that makes sure that the chromosomes are divided correctly between cells," says Whitehead Member Iain Cheeseman. The findings are published in this week's issue of Molecular Cell. During cell division, the cell's DNA is consolidated into X-shaped chromosome pairs that...