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LAKE FOREST, Ill., Jan.
Atrial fibrillation is an irregular heartbeat (arrhythmia) in which the atria, or upper chambers of the heart, beat quickly and inconsistently. Expression of potassium channel KCNA5 is confined to cells in the atria and not the ventricle, making it a target for the development of drugs to treat atrial fibrillation. Polymorphisms in KCNA5 have been identified, which make the potassium channel less sensitive to blockade by antiarrhythmic drugs, but appear otherwise indistinguishable from normal...
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