Latest Idiopathic CD4+ lymphocytopenia Stories
The hallmark loss of helper CD4+ T cells during human immunodeficiency virus (HIV) infection may be a red herring for therapeutics.
Using data from the Collaboration of Observational HIV Epidemiological Research in Europe (COHERE), Jim Young and colleagues from The Opportunistic Infections Project Team of COHERE show in this week's PLoS Medicine that in successfully treated patients, the risk of a new AIDS event or death follows a CD4 cell count gradient in patients with viral suppression.
A new report from the Naval Medical Center in San Diego said that CD4+ cell counts among newly-diagnosed HIV patients in the U.S. fell from 1985 to 2007, suggesting the virus may be growing more virulent.
HIV infection decreases the number of CD4+ T lymphocytes and this increases the risk of infection. Administration of IL-2 to HIV-infected people can boost CD4 cell number, but the mechanisms underlying this were not clear.
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