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Latest Immune receptor Stories

2013-05-01 12:34:12

St. Jude Children's Research Hospital advances understanding of how T cells craft an appropriate immune response; setting the stage for new strategies to intervene if the system goes awry A properly functioning immune system is a lesson in balance, providing protection against disease without attacking healthy tissue. Work led by St. Jude Children's Research Hospital scientists and published recently in Nature Immunology has identified a mechanism that helps T cells find that sweet spot...

2012-03-14 20:48:18

Researchers identify 190 genes crucial to the function of TLR7 and TLR9, cellular sensors that recognize pathogens and trigger immune responses -- providing insights that could be exploited to develop new therapies for infectious and autoimmune diseases In a healthy immune system, invading pathogens trigger a cascade of alerts and responses to fight off the infection. Sensors called toll-like receptors, or TLRs, act as one of the first lines of defense. Two of these sensors, known as TLR7...

2011-10-21 13:47:10

Exceptional cognitive and physical function in old age leaves a tell-tale immunologic fingerprint, say researchers at the University of Pittsburgh and Children's Hospital of Pittsburgh of UPMC. Likewise, older adults who have mild impairments bear a distinct immunologic pattern, too, according to findings published today in the Public Library of Science: One. Old age is not synonymous with impairment and disability, noted lead investigator Abbe N. de Vallejo, Ph.D., associate professor of...

2011-04-29 15:52:28

Cedars-Sinai research offers model Scientists at Cedars-Sinai Medical Center have discovered how a molecular receptor on the surface of white blood cells identifies when invading fungi have established direct contact with the cell surface and pose an infectious threat. The receptor called Dectin-1, studied in the laboratory of David Underhill, PhD, an associate professor in Cedars-Sinai's Inflammatory Bowel and Immunobiology Research Institute, detects fungi and instructs white blood cells...

2010-11-05 15:50:03

Although human and chimpanzee immune systems have many identical components, this is not the case for the family of killer cell immunoglobulin-like receptors (KIR) controlling white blood cells known as natural killer (NK) cells. Published in the open-access journal PloS Genetics on November 4, a paper by Stanford University researchers describes qualitative KIR differences, acquired after humans and chimpanzees separated 6 million years ago and mainly a consequence of innovation in the human...

2009-11-20 14:32:50

Researchers at the University of Alabama at Birmingham (UAB) have uncovered the genetic identity of a cellular receptor for the immune system's first-response antibody, a discovery that sheds new light on infection control and immune disorders. The discovery is such a crucial part of immunology that UAB researchers, in conjunction with Japanese researchers, are asking that the gene linked to this antibody receptor be renamed to better describe its role in early immune responses. The proposed...

2009-06-29 09:55:27

Important modulator of immune cell entry into the brain -- perhaps new target for the therapyIt has been known for a long time that T cells can attack the body's own structures and, if they infiltrate the CNS, cause diseases such as multiple sclerosis (MS). The T cells damage the myelin sheath, the material that surrounds and protects the fibers of nerve cells. This damage slows down or blocks messages between the brain and the body, leading to various symptoms of MS such as impaired...

2009-06-01 10:25:00

A review article published in the FASEB Journal shows that death receptors may be prime therapeutic targets for treating a wide variety of cancers, immune disorders and tissue injuriesIt turns out that from the perspective of cell biology, Nietzsche may have been right after all: that which does not kill us does make us stronger. In a review article published in the June 2009 print issue of The FASEB Journal (http://www.fasebj.org), scientists from the Mayo Clinic explain how cell receptors...

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2009-04-21 08:10:00

New study in the FASEB Journal shows that our brains make proteins that act directly on the marijuana receptors in our head U.S. and Brazilian scientists have just proven that one of Bob Dylan's most famous lines"”"everybody must get stoned""” is correct. That's because they've discovered that the brain manufactures proteins that act like marijuana at specific receptors in the brain itself. This discovery, published online in The FASEB Journal, may lead to new marijuana-like drugs...

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2008-10-28 10:05:00

Dutch researcher Joost Wiersinga from AMC Medical Centre in Amsterdam has unravelled a genetic defence mechanism against the lethal bacteria Burkholderia pseudomallei. The research is the next step towards a vaccine against this bacterium suitable for bioweapons.Humans have an innate defence system against deadly bacteria. However, how the step from gene to anti-bacterial effect occurs in the body is not yet known. To date, B. Pseudomallei, a bacterium suitable for bioweapons, had managed to...


Word of the Day
kenspeckle
  • Having so marked an appearance as easily to be recognized.
This word may come from the Swedish 'kanspak,' quick at recognizing persons or things, or else from confusion with 'conspicuous.'