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Latest Immune tolerance Stories

2013-09-10 11:09:13

UCSF experiments halt pancreas destruction in mouse model of diabetes Scientists from UC San Francisco have identified a new way to manipulate the immune system that may keep it from attacking the body’s own molecules in autoimmune diseases such as type 1 diabetes, rheumatoid arthritis and multiple sclerosis. The researchers, led by immunologist Mark Anderson, MD, PhD, a professor with the UCSF Diabetes Center, have discovered a distinctive type of immune cell called an eTAC, which...

2012-02-14 11:25:52

At the most basic level, the immune system must distinguish self from non-self, that is, it must discriminate between the molecular signatures of invading pathogens (non-self antigens) and cellular constituents that usually pose no risk to health (self-antigens). The system is far from foolproof. Cancer cells can undergo unchecked proliferation, producing self-antigens that are tolerated by the immune system, rather than being targeted for destruction. At the opposite extreme, a range of...

2011-09-29 22:39:10

New research published in the Journal of Leukocyte Biology demonstrates how the human intestine generates and maintains 'immune tolerance' under healthy conditions Imagine a single drug that would treat most, if not all, autoimmune disorders, such as asthma, inflammatory bowel disease, and Lupus. That might not be so hard to do thanks to a team of researchers who have discovered a molecule normally used by the body to prevent unnecessary immune reactions. This molecule, pronounced "alpha v...

2011-09-19 22:24:18

Within the immune system, a subtle balance exists between the cells that destroy alien pathogens and those that preserve the body's own tissues. When the balance gets out of whack, the cells that normally target viruses or bacteria can go astray, attacking innocent cells and causing autoimmune and inflammatory disease. Now, researchers at the University of North Carolina at Chapel Hill have revealed the genetic underpinnings of the cells —called Foxp3-expressing regulatory T cells or...

2011-09-15 20:02:18

It is no easy task to preserve the delicate balance that allows us to maintain a strong immune system that can defend us from harmful pathogens, but that is sensitive enough to correctly identify and spare our own cells. Therefore, it is not surprising that the mechanisms that underlie immune activation and tolerance are not completely understood. Now, a new research study published by Cell Press in the journal Immunity and available online on September 15th provides intriguing insight into...

2010-07-01 16:36:19

Understanding of mouse immune-system response to specific fetal antigens also may provide insight into issues that arise during human pregnancies The concept of pregnancy makes no sense"”at least not from an immunological point of view. After all, a fetus, carrying half of its father's genome, is biologically distinct from its mother. The fetus is thus made of cells and tissues that are very much not "self""”and not-self is precisely what the immune system is meant to search out...

2009-08-17 11:17:00

--However, Animal Study Also Points Toward Strategies for Success-- PHILADELPHIA, Aug. 17 /PRNewswire-USNewswire/ -- Pediatric researchers have resolved an apparent contradiction in the field of prenatal cell transplantation -- a medical approach that holds future promise in correcting sickle cell disease and other serious congenital blood disorders. In a new study in animals, the researchers showed that the mother's immune response interferes with the offspring's earlier ability to...

2009-08-17 11:34:06

Pediatric researchers have resolved an apparent contradiction in the field of prenatal cell transplantation"” a medical approach that holds future promise in correcting sickle cell disease and other serious congenital blood disorders. In a new study in animals, the researchers showed that the mother's immune response interferes with the offspring's earlier ability to tolerate transplanted donor cells.The study team concludes that focusing on transplant techniques that avoid the maternal...

2009-06-15 11:17:30

The immune system's T-cells react to foreign protein fragments and therefore are crucial to combating viruses and bacteria. Errant cells that attack the body's own material are in most cases driven to cell death. Some of these autoreactive T-cells, however, undergo a kind of reeducation to become "regulatory T-cells" that keep other autoreactive T-cells under control. A group led by immunologist Professor Ludger Klein of LMU Munich has now shown that the developmental stage of an autoreactive...


Word of the Day
caparison
  • A cloth or covering, more or less ornamented, laid over the saddle or furniture of a horse, especially of a sumpter-horse or horse of state.
  • Clothing, especially sumptuous clothing; equipment; outfit.
  • To cover with a caparison, as a horse.
  • To dress sumptuously; adorn with rich dress.
This word ultimately comes from the Medieval Latin 'cappa,' cloak.
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