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Last updated on April 23, 2014 at 13:24 EDT

Latest Immunohistochemistry Stories

2008-07-31 09:00:28

SUNNYVALE, Calif., July 31 /PRNewswire/ -- Pathwork Diagnostics, Inc., a molecular diagnostics company focused on oncology, today announced that the U.S. Food and Drug Administration (FDA) has cleared its Pathwork(R) Tissue of Origin Test for use in determining the origin of uncertain tumors. The test analyzes a tumor's gene expression pattern to help pinpoint the source of hard-to-identify tumors and is the first test of its kind to receive FDA clearance. Up to an estimated 200,000 newly...

2008-07-02 06:00:47

By Jensen, Kristin Theory and Practice of Histological Techniques, 6th Edition John D. Bancroft and Marilyn Gamble, editors Churchill Livingstone Elsevier Philadelphia, PA. Copyright (c) 2008 725 pages, $219.00, Hardcover This comprehensive text on histological methods is a well- organized, concise yet thorough reference designed for students of histology but suitable for a wide range of technicians and scientists in clinical and experimental settings. The authors focus on preserving...

2008-06-25 03:01:46

By Fisher, Ronald E Siegel, Barry A; Edell, Steven L; Oyesiku, Nelson M; Morgenstern, David E; Messmann, Richard A; Amato, Robert J ^sup 99m^Tc-EC20 is a folate receptor (FR)-targeted imaging agent consisting of the vitamin folate conjugated to ^sup 99m^Tc. FR is expressed on a variety of epithelial cancers, with advanced cancers often expressing FR at significantly higher levels than earlier stages of the disease. The goals of this pilot study were to determine the percentages of various...

2008-03-19 09:00:09

Targeted Molecular Diagnostics, LLC (TMD) announces the availability of the PhosphoGuard(TM) kit for preservation of phosphoproteins during tissue fixation and processing. When used as an additive to conventional fixatives, PhosphoGuard(TM) can prevent degradation of phosphorylated or "activated" proteins in patient tissue or xenograft specimens. Phosphorylated proteins are useful markers that may be essential in predicting patient response or resistance to targeted cancer therapies....

2008-02-13 03:00:14

By Deavers, Michael T Although most diagnoses in gynecologic pathology are established through the examination of routine hematoxylin eosin-stained slides, immunohistochemical studies can be of assistance in some cases. The following case studies are used to illustrate the value of some relatively new markers in the diagnosis of gynecologic neoplasms and to highlight potential diagnostic pitfalls. (Arch Pathol Lab Med. 2008;132:175-180) CASE 1 Case History The patient is a 59-year-old...

2008-01-16 03:00:13

By Yip, Stephen Iafrate, A John; Louis, David N Abstract Advances in understanding the molecular underpinnings of cancer and in molecular diagnostic technologies have changed the clinical practice of oncologic pathology. The development of targeted therapies against specific molecular alterations in cancer further portends changes in the role of the pathology laboratory to guide such custom therapies. To reconcile the flood of scientific discoveries in this area, the promises of highly...

2007-12-22 06:00:33

By Frattini, Jared C Sosa, Julie Ann; Carmack, Susanne; Robert, Marie E * Data from the nuclear reactor explosion in Chernobyl and the atomic bomb detonations in Hiroshima and Nagasaki demonstrated an association between ionizing radiation and tumoriogenesis. There is a significant association between external beam radiation and radiation-induced sarcoma. Sclerosing epithelioid fibrosarcoma is a rare form of malignant fibrosarcoma that is low grade and indolent with distinct...

2007-08-16 06:16:45

By Liu, Lina Qian, Junqi; Singh, Harpreet; Meiers, Isabelle; Et al Context.-The separation of chromophobe renal cell carcinoma, oncocytoma, and clear cell renal cell carcinoma using light microscopy remains problematic in some cases. Objective.-To determine a practical immunohistochemical panel for the differential diagnosis of chromophobe carcinoma. Design.-Vimentin, glutathione S-transferase alpha (GST-alpha), CD10, CD117, cytokeratin (CK) 7, and epithelial cell adhesion molecule...

2007-02-14 09:00:00

By Takei, Hidehiro; Bhattacharjee, Meenakshi B; Rivera, Andreana; Dancer, Yeongju; Powell, Suzanne Z * Context.-Immunohistochemistry (IHC) has become an important tool in the diagnosis of brain tumors. Objective.-To review the latest advances in IHC in the diagnostic neuro-oncologic pathology. Data Sources.-Original research and review articles and the authors' personal experiences. Data Synthesis.-We review the features of new, useful or potentially applicable marker antibodies as well...