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Latest Immunologic adjuvant Stories

2014-01-23 04:21:21

Inovio develops DNA-based immune booster (IL-33) that enhances T-cell responses and generates effective CD8 mediated tumor regression BLUE BELL, Pa., Jan. 23, 2014 /PRNewswire/ -- Inovio Pharmaceuticals, Inc. (NYSE MKT: INO) today unveiled that the company has developed a new DNA-based cytokine immune activator, interleukin -33 (IL-33), that in combination with optimized DNA vaccines delivered by electroporation increased the potency and efficacy of the therapeutic response to the...

2013-12-12 12:14:07

Pretreatment with near-infrared laser also could improve response to additional intradermal vaccines Pretreating the site of intradermal vaccination – vaccine delivered into the skin rather than to muscles beneath the skin – with a particular wavelength of laser light may substantially improve vaccine effectiveness without the adverse effects of chemical additives currently used to boost vaccine efficacy. In the open-access journal PLOS ONE, investigators from Vaccine and Immunotherapy...

2013-04-08 12:14:47

Aluminum salts, or alum, have been injected into billions of people as an adjuvant to make vaccines more effective. No one knows, however, how they boost the immune response. In the March 19, 2013, issue of the Proceedings of the National Academy of Sciences researchers at National Jewish Health continue unraveling the mystery of adjuvants with a report that host DNA coats the alum adjuvant and induces two crucial cells to interact twice as long during the initial stimulation of the adaptive...

2013-03-05 10:44:28

Promising compound may help protect babies during vulnerable window The underdeveloped immune systems of newborns don't respond to most vaccines, leaving them at high risk for infections like rotavirus, pertussis (whooping cough) and pneumococcus. Researchers at Boston Children's Hospital have identified a potent compound that activates immune responses in newborns' white blood cells substantially better than anything previously tested, and that could potentially make vaccines effective...

Better Vaccines Through Designer Bacteria
2013-01-16 04:49:54

Connie K. Ho for redOrbit.com — Your Universe Online Scientists from the University of Texas-Austin (UTA) recently revealed that they have been able to develop 61 new strains of genetically engineered bacteria that could boost the effectiveness of vaccines for diseases such as cholera, HPV, the flu, and pertussis. The findings on these strains of E. coli were featured in a recent edition of the Proceedings of the National Academy of Sciences. These strains of E. coli are part of a...

2012-07-16 11:14:56

1. Scientists at A*STAR´s Singapore Immunology Network (SIgN), in collaboration with Newcastle University, UK, the Singapore Institute of Clinical Sciences and clinicians from multiple hospitals in Singapore, have identified a new subset of dendritic cells (DCs) in human peripheral tissue which have a critical role in activating our immune response against harmful pathogens. This research will have significant impact on the design of vaccines and other targeted immunotherapies. The...

2012-04-05 21:14:17

The discovery of how a vital immune cell recognises dead and damaged body cells could modernise vaccine technology by 'tricking' cells into launching an immune response, leading to next-generation vaccines that are more specific, more effective and have fewer side-effects. Scientists from the Walter and Eliza Hall Institute have identified, for the first time, how a protein found on the surface of immune cells called dendritic cells recognises dangerous damage and trauma that could signify...

2012-03-27 10:37:25

Innovative TAU tool for immune system activation could lead to better drug delivery Developing a drug or vaccine requires a delicate balancing act with the immune system. On one hand, medications need to escape detection by the immune system in order to perform their function. But vaccinations – de-activated versions of a disease or virus – need to do the reverse. They prompt the immune system to create protective antibodies. But scientists are still stumped by how the immune...

2012-02-08 14:50:52

Immunological diseases, such as eczema and asthma, are on the increase in westernised society and represent a major challenge for 21st century medicine. A new study has shown, for the first time, that growing up on a farm directly affects the regulation of the immune system and causes a reduction in the immunological responses to food proteins. The research, led by the University of Bristol's School of Veterinary Sciences, found that spending early life in a complex farm environment...