Quantcast

Latest INIT II Stories

2012-02-02 07:51:11

The development of a medicine for patients with type 1 diabetes mellitus, based on autoantigen GAD65, received a setback following crucial clinical phase 3 trials that failed to show significant effects. One possible explanation may be seasonal variations in the immune system, claim those responsible for the study that was published in the New England Journal of Medicine (NEJM). At the onset of type 1 diabetes mellitus, the immune system attacks the insulin-producing pancreatic beta-cells....

Insulin Nasal Spray Could Improve Alzheimer's Symptoms
2011-09-13 11:44:01

  U.S. researchers said on Monday that a daily squirt of insulin through the nose could help improve memory skills in people with Alzheimer's. The study involved 104 patients with mild cognitive decline or mild to moderate Alzheimer's disease. The experts say that their findings need to be confirmed in larger, longer trials, but they said it was a welcome advance at a time when few treatments have shown any sign of improving memory troubles in these patients. The researchers...

2011-09-12 23:30:17

Intranasal insulin therapy appears to provide some benefit for cognitive function in patients with amnestic mild cognitive impairment and Alzheimer disease, according to a report published Online First today by Archives of Neurology, one of the JAMA/Archives journals. According to background information in the article, insulin plays a role in a number of functions of the central nervous system. "The importance of insulin in normal brain function is underscored by evidence that insulin...

2011-06-29 12:11:21

A chemical produced by the same cells that make insulin in the pancreas prevented and even reversed Type 1 diabetes in mice, researchers at St. Michael's Hospital have found. Type 1 diabetes, formerly known as juvenile diabetes, is characterized by the immune system's destruction of the beta cells in the pancreas that make and secrete insulin. As a result, the body makes little or no insulin. The only conventional treatment for Type 1 diabetes is insulin injection, but insulin is not a cure...

2010-11-11 13:57:13

A Finnish study shows that dietary intervention in infancy can prevent the initiation of the disease process leading to Type 1 diabetes among high-risk children A Finnish study confirms the hypothesis that infant feeding plays a role in the initiation of the disease process leading to type 1 diabetes in children carrying increased genetic disease risk. The study population comprised 230 newborn infants with at least one family member affected by type 1 diabetes and a predisposing genotype...

2010-09-23 06:30:00

STOCKHOLM, Sept. 23 /PRNewswire/ -- Tolerx, Inc., a biopharmaceutical company developing novel therapies to treat autoimmune diseases and cancer by modulating T cell activity, today announced the presentation of preclinical research describing the mechanism of action of otelixizumab at the 46th Annual Meeting of the European Association for the Study of Diabetes (EASD). In addition, Tolerx also announced that the first European patient was enrolled in DEFEND-2, a confirmatory Phase 3...

88bbb4a5a50745dda17ae6ccc6ae0d1f1
2009-07-23 14:30:00

New Zealand-based biotech company Living Cell Technologies has launched an experiment that will place pig cells into eight volunteer participants. Derived from piglets, the implanted cells create pig insulin, which contains similar properties to human insulin. Researchers hope the trial will result in a noticeably lower blood sugar level and negate or delay the effects of Type 1 diabetes. Professor Bob Elliott, medical director of LCT, said the cells were taken from pigs that lived in...

2009-04-30 09:37:27

Scientists believe they may have found a preventative therapy for Type 1 diabetes, by making the body's killer immune cells tolerate the insulin-producing cells they would normally attack and destroy, prior to disease onset.Type 1 diabetes is an autoimmune condition, where the body attacks its own insulin producing cells. It is very serious, with a sudden and dramatic onset, usually in youth. People with Type 1 diabetes must maintain an insulin-monitoring and insulin-injecting regimen for the...

2008-08-06 09:00:11

CAMBRIDGE, Mass., Aug. 6 /PRNewswire/ -- Tolerx, Inc., a biopharmaceutical company engaged in the discovery and development of novel therapies for immune-mediated diseases, today announced the initiation of a pivotal Phase 3 clinical trial that is evaluating otelixizumab in autoimmune new onset type 1 diabetes. As a result of the initiation of patient dosing in DEFEND (Durable Response Therapy Evaluation For Early or New Onset Type 1 Diabetes), Tolerx will receive a $15 million milestone...


Word of the Day
callithump
  • A somewhat riotous parade, accompanied with the blowing of tin horns, and other discordant noises; also, a burlesque serenade; a charivari.
'Callithump' is a back-formation of 'callithumpian,' a 'fanciful formation' according to the Oxford English Dictionary. However, the English Dialect Dictionary, says 'Gallithumpians' is a Dorset and Devon word from the 1790s that refers to 'a society of radical social reformers' or 'noisy disturbers of elections and meetings.'
Related