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Last updated on April 17, 2014 at 8:20 EDT

Latest Innate immune system Stories

2011-08-05 13:58:06

Novel DNA sensing pathway linked to increased susceptibility to malaria Scientists at the University of Massachusetts Medical School have uncovered a novel DNA-sensing pathway important to the triggering of an innate immune response for malaria. Activation of this pathway appears to stimulate production of an overabundance of type-1 interferon by the immune system that may contribute to inflammation and fever in malaria patients and could play a part in susceptibility for the most common and...

2011-08-05 12:57:44

Innate memory provides protection against vaccinia Researchers have demonstrated that cells of the innate immune system are capable of "memory", and of mounting rapid protection to an otherwise lethal dose of live vaccinia virus. The study, published in the Open Access journal PLoS Pathogens on August 4th, challenges previous thought that only B cells and T cells can store memory to ward off future infection. The finding, by researchers from Beth Israel Deaconess Medical Center, Harvard...

2011-06-16 12:48:24

Tempering the immune response -- rather than enhancing it -- in asthma patients might be a better strategy when combating cold symptoms People often talk about "boosting" their immunity to prevent and fight colds. Nutritional supplements, cold remedies and fortified foods claim to stave off colds by augmenting the immune system. A new University of Michigan study shows this strategy might actually be flawed. The results may hold important implications for individuals with asthma, who often...

2011-05-23 22:16:45

A group of proteins that act as the body's built-in line of defense against invading bacteria use a molecular trick to induce bacteria to destroy themselves, researchers at the Indiana University School of Medicine have determined. The research could point the way toward new anti-bacterial treatments that could take on bacteria that are resistant to antibiotics. The proteins, called Peptidoglycan Recognition Proteins (PGRPs), are able to detect and target bacteria because bacteria are unique...

2010-12-20 15:34:06

New research by scientists at the University of California, San Diego School of Medicine and Skaggs School of Pharmacy and Pharmaceutical Sciences reveals that the immune system has an effective backup plan to protect the body from infection when the "master regulator" of the body's innate immune system fails. The study appears in the December 19 online issue of the journal Nature Immunology. The innate immune system defends the body against infections caused by bacteria and viruses, but also...

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2010-11-22 06:43:34

Though it's been at least a billion years since plants and animals shared a common ancestor, they have through the eons shared a common threat in the form of microbes, including bacteria, eukaryotes and viruses. This has resulted in remarkably similar mechanisms for detecting the molecular signatures of infectious organisms that hold promise for the future treatment of infectious diseases in humans. The recognition of microbial signature molecules by host receptors is the subject of a paper...

2010-11-18 16:44:07

New research reveals a clever strategy that enables a host organism to outsmart an invading bacterium by counteracting its efforts to suppress the innate immune response. The study, published by Cell Press in the November 24th issue of the journal Immunity, describes a mechanism by which an infected cell can quickly alert unsuspecting (and uninfected) neighboring cells that can join the fight, amplify the immune response and defeat the invader. The pathogen Shigella flexneri invades the cells...

2010-09-22 20:15:13

Researchers funded by the Biotechnology and Biological Sciences Research Council (BBSRC) have established in mice the mechanism that detects and responds to the presence of bacteria in the womb - a discovery that opens up the possibility of new preventative treatments for diseases like pelvic inflammatory disease and Chlamydia. The work, led by Professor Martin Sheldon from Swansea University's School of Medicine, is published today (22 September) in PLoS ONE. Professor Sheldon said:...

2010-09-08 14:41:16

Scientists from the University of California, San Diego School of Medicine have identified dendritic antigen-presenting cells in zebrafish, opening the possibility that the tiny fish could become a new model for studying the complexities of the human immune system. The study, reported in the online edition of the Proceedings of the National Academy of Sciences, was headed by David Traver, an associate professor in UCSD's Department of Cellular and Molecular Medicine, with colleagues in UCSD's...

2010-08-31 20:53:29

New research published in the Journal of Leukocyte Biology suggests that our innate immune systems are a major contributor to chronic lung diseases like silicosis For the nearly 2 million U.S. workers exposed to silica dust each year, a new discovery may help prevent or treat the development of chronic lung diseases related to this exposure. In the September 2010 issue of the Journal of Leukocyte Biology (http://www.jleukbio.org) scientists from Montana and Texas use mice to show for the...