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Latest Integral membrane proteins Stories

Birth-defect Mystery Solved By BYU Biochemistry Professor And Students
2012-09-12 12:20:17

The cellular cause of birth defects like cleft palates, missing teeth and problems with fingers and toes has been a tricky puzzle for scientists. Now Professor Emily Bates and her biochemistry students at Brigham Young University have placed an important piece of the developmental puzzle. They studied an ion channel that regulates the electrical charge of a cell. In a new study published by the journal Development, they show that blocking this channel disrupts the work of a protein that is...

Double Whammy From Brain Enzyme For Alzheimer's Disease
2012-08-20 08:22:40

Sanford-Burnham researchers discover that an enzyme known for generating toxic brain plaques in Alzheimer's disease also causes additional memory and cognitive deficits via a separate mechanism The underlying causes of Alzheimer's disease are not fully understood, but a good deal of evidence points to the accumulation of β-amyloid, a protein that's toxic to nerve cells. β-amyloid is formed by the activity of several enzymes, including one called BACE1. Most Alzheimer's disease...

2012-07-30 12:15:10

Stowers scientists make a surprising find in study of sex- and aggression-triggering vomeronasal organ The vomeronasal organ (VNO) is one of evolution's most direct enforcers. From its niche within the nose in most land-based vertebrates, it detects pheromones and triggers corresponding basic-instinct behaviors, from compulsive mating to male-on-male death matches. A new study from the Stowers Institute for Medical Research, published online in Nature Neuroscience on July 29, 2012, extends...

2012-07-25 13:00:38

A study, performed in mice and utilizing post-mortem samples of brains from patients with Alzheimer's disease, found that a single event of a moderate-to-severe traumatic brain injury (TBI) can disrupt proteins that regulate an enzyme associated with Alzheimer's. The paper, published in The Journal of Neuroscience, identifies the complex mechanisms that result in a rapid and robust post-injury elevation of the enzyme, BACE1, in the brain. These results may lead to the development of a drug...

2012-07-13 08:20:01

Tokyo, July 13, 2012 - (JCN Newswire) - Eisai Co., Ltd. announced today that first data from clinical studies with E2609, a BACE (beta-site amyloid precursor protein-cleaving enzyme) inhibitor discovered in-house, will be presented during oral sessions at the Alzheimer's Association International Conference (AAIC) 2012, taking place in Vancouver, Canada from July 14 to 19, 2012. E2609 is a BACE inhibitor currently being developed by Eisai as a next-generation oral Alzheimer's disease...


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