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Latest Integral membrane proteins Stories

2012-07-12 23:01:25

Sophion and CreaCell announced today that the two companies successfully demonstrated the performances of HEK-hKir2.1 cells on QPatch HT. (PRWEB) July 12, 2012 Inward rectifier potassium channels of the Kir2 subfamily are important determinants of the electrical activity of cardiac cells, and mutations of the Kir2.1 channels are associated with familial atrial fibrillation, Andersen-Tawil syndrome and short-QT syndrome. Because human Kir2.1 is a relevant target in preclinical cardiac...

Small Molecule Might Play Big Role In Alzheimer's Disease
2012-07-10 10:58:00

Simulations by UC Santa Barbara researchers improve understanding of plaque formation and suggest new diagnostic and treatment options Alzheimer's disease is one of the most dreaded and debilitating illnesses one can develop. Currently, the disease afflicts 6.5 million Americans and the Alzheimer's Association projects it to increase to between 11 and 16 million, or 1 in 85 people, by 2050. Cell death in the brain causes one to grow forgetful, confused and, eventually, catatonic....

2012-07-02 21:37:07

Research published today in Biomed Central's open access journal Journal of Neuroinflammation suggests that chronic inflammation can predispose the brain to develop Alzheimer's disease. To date it has been difficult to pin down the role of inflammation in Alzheimer's disease (AD), especially because trials of NSAIDs appeared to have conflicting results. Although the ADAPT (The Alzheimer`s Disease Anti-inflammatory Prevention Trial) trial was stopped early, recent results suggest that...

2012-06-27 17:29:28

In a recent Journal of Biological Chemistry "Paper of the Week," research led by Ayae Kinoshita at the Kyoto University Graduate School of Medicine in Japan reveals the benefits of exercise in combating Alzheimer's disease. The most common cause of dementia, Alzheimer's disease results in the loss of cognitive faculty. In the majority of cases, Alzheimer's disease occurs after age 65, and factors such as diet and exercise appear to play a role in its development, with high-fat diets as a...

2012-06-26 10:27:44

Scientists from Queen Mary, University of London have discovered a mechanism that controls the way that organisms breathe or photosynthesize, potentially paving the way for improved biofuel production. Writing in the journal PNAS, Dr Lu-ning Lu and Professor Conrad Mullineaux from Queen Mary's School of Biological and Chemical Sciences report that by exposing cells to different light conditions, they have changed the way in which electrons are transported. Professor Mullineaux explains:...

2012-06-20 11:13:47

Amyloid fibers in the brain are a hallmark of many neurodegenerative diseases, including Parkinson's disease, for which there are no effective treatments. These fibers result from aggregation of a specific protein in each disease–in Parkinson's, for example, the aggregated protein is called alpha-synuclein. Although amyloid fibers are implicated in numerous pathologies, they can also play beneficial, protective roles. In yeast, for example, they are associated with increased survival...

2012-06-16 00:48:48

Recent work in mice suggested that the immune system is involved in removing beta-amyloid, the main Alzheimer's-causing substance in the brain. Researchers have now shown for the first time that this may apply in humans. Researchers at the Peninsula College of Medicine and Dentistry, University of Exeter with colleagues in the National Institute on Aging in the USA and in Italy screened the expression levels of thousands of genes in blood samples from nearly 700 people. The telltale marker...

2012-06-11 21:50:23

Researchers work to untangle knots, slipknots in species separated by a billion years of evolution Strings of all kinds, when jostled, wind up in knots. It turns out that happens even when the strings are long strands of molecules that make up proteins. A new study by scientists at Rice University and elsewhere examines structures of proteins that not only twist and turn themselves into knots, but also form slipknots that, if anybody could actually see them, might look like shoelaces...

2012-06-05 10:01:37

A new study suggests that protein knots, a structure whose formation remains a mystery, may have specific functional advantages that depend on the nature of the protein's architecture. "The presence of a knotted or slipknotted structure in a protein is relatively rare but really is very interesting," said Kenneth Millett, a professor of mathematics at UC Santa Barbara and a co-author of the paper, "Conservation of complex knotting and slipknotting patterns in proteins," published in the...


Word of the Day
sough
  • A murmuring sound; a rushing or whistling sound, like that of the wind; a deep sigh.
  • A gentle breeze; a waft; a breath.
  • Any rumor that engages general attention.
  • A cant or whining mode of speaking, especially in preaching or praying; the chant or recitative characteristic of the old Presbyterians in Scotland.
  • To make a rushing, whistling, or sighing sound; emit a hollow murmur; murmur or sigh like the wind.
  • To breathe in or as in sleep.
  • To utter in a whining or monotonous tone.
According to the OED, from the 16th century, this word is 'almost exclusively Scots and northern dialect until adopted in general literary use in the 19th.'
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