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Latest Integral membrane proteins Stories

2012-04-04 09:25:27

Improvement shown in blood vessel function following drug treatment A cholesterol drug commonly prescribed to reduce cardiovascular disease risk restores blood vessel function in a mouse model of Alzheimer's disease, according to a study in the April 4 issue of The Journal of Neuroscience. The drug simvastatin (Zocor®) – which works by slowing cholesterol production – also improves learning and memory in adult, but not aged Alzheimer's model mice. The findings add to a...

2012-03-12 09:54:17

A team of researchers at Duke University has determined the structure of a key molecule that can carry chemotherapy and anti-viral drugs into cells, which could help to create more effective drugs with fewer effects to healthy tissue. "Knowing the structure and properties of the transporter molecule may be the key to changing the way that some chemotherapies, for example, could work in the body to prevent tumor growth," said senior author Seok-Yong Lee, Ph.D., assistant professor of...

2012-03-08 01:03:09

Researchers at the University of California, San Diego, the Medical University of South Carolina, the University of Cincinnati, and American Life Science Pharmaceuticals of San Diego have validated the protease cathepsin B (CatB) as a target for improving memory deficits and reducing the pathology of Alzheimer's disease (AD) in an animal model representative of most AD patients. The study has been published in the online edition of the Journal of Alzheimer's Disease. According to...

2012-03-01 11:02:05

Neuroscientists show that HDAC2 enzyme could be a good target for new drugs MIT neuroscientists have shown that an enzyme overproduced in the brains of Alzheimer's patients creates a blockade that shuts off genes necessary to form new memories. Furthermore, by inhibiting that enzyme in mice, the researchers were able to reverse Alzheimer's symptoms. The finding suggests that drugs targeting the enzyme, known as HDAC2, could be a promising new approach to treating the disease, which...

2012-03-01 01:56:53

In a mouse model of Alzheimer's disease, memory problems stem from an overactive enzyme that shuts off genes related to neuron communication, a new study says. When researchers genetically blocked the enzyme, called HDAC2, they 'reawakened' some of the neurons and restored the animals' cognitive function. The results suggest that drugs that inhibit this particular enzyme would make good treatments for some of the most devastating effects of the incurable neurodegenerative disease. "It's...

2012-02-20 15:02:27

In two landmark papers in the journal Nature this week, scientists at The Scripps Research Institute report that they have identified a class of proteins that detect "painful touch." Scientists have known that sensory nerves in our skin detect pressure, pain, heat, cold, and other stimuli using specialized "ion channel" proteins in their outer membranes. They have only just begun, however, to identify and characterize the specific proteins involved in each of these sensory pathways. The...

2012-02-14 11:46:28

Curcumin, a substance extracted from turmeric, prolongs life and enhances activity of fruit flies with a nervous disorder similar to Alzheimers. The study conducted at Linköping University, indicates that it is the initial stages of fibril formation and fragments of the amyloid fibrils that are most toxic to neurons. Ina Caesar, as the lead author, has published the results of the study in the prestigious journal PLoS One. For several years curcumin has been studied as a...

2012-02-14 11:00:00

That flutter in your heart may have more to do with the movement of sodium ions than the glance of a certain someone across a crowded room. Using the Canadian Light Source synchrotron, researchers from the University of British Columbia have revealed, for the first time, one of the molecular mechanisms that regulates the beating of heart cells by controlling the movement of sodium in out of the cells — and what calcium has to do with it. The findings, published February 14 in the...

2012-01-27 16:04:28

Researchers discover dual role of key player in immune system Northwestern University Feinberg School of Medicine researchers have identified a new and unusual role for a key player in the human immune system. A protein initially believed to regulate one routine function within the cell has proven vital for another critical step in the activation of the immune system. That protein, STIM1, was previously known to sense a change in calcium within immune cells, a process that occurs when...


Word of the Day
tesla
  • The unit of magnetic flux density in the International System of Units, equal to the magnitude of the magnetic field vector necessary to produce a force of one newton on a charge of one coulomb moving perpendicular to the direction of the magnetic field vector with a velocity of one meter per second. It is equivalent to one weber per square meter.
This word is named for Nikola Tesla, the inventor, engineer, and futurist.