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Latest Integral membrane proteins Stories

2011-10-03 22:23:47

Laser technique allows detailed view of the early minutes of amyloid aggregate formation -- implications for Alzheimer's disease drug discovery Researchers at the University of Toronto Scarborough (UTSC) and Osaka University applied a new approach to take a close look at amyloid plaque formation, a process that plays important roles in Alzheimer's disease. The technique would greatly aid the development and screening for novel therapeutics that can manipulate the formation of the toxic...

2011-09-27 12:58:18

Up-and-down cycle flattens as age disrupts pattern A marker for Alzheimer's disease rises and falls in the spinal fluid in a daily pattern that echoes the sleep cycle, researchers at Washington University School of Medicine in St. Louis have found. The pattern is strongest in healthy young people and reinforces a link between increased Alzheimer's risk and inadequate sleep that had been discovered in animal models. The brain's relative inactivity during sleep may provide an opportunity...

2011-09-09 13:29:04

Ion channels ensure the heart keeps time The heartbeat is the result of rhythmic contractions of the heart muscle, which are in turn regulated by electrical signals called action potentials. Action potentials result from the controlled flow of ions into heart muscle cells (depolarization) through channels in their membranes, and are followed by a compensating reverse ion current (repolarization), which restores the original state. If the duration of the repolarization phase is not just...

2011-09-07 19:35:01

Alzheimer's disease (AD) is a devastating neurodegenerative disorder that causes progressive cognitive impairment and memory loss. Now, a new study published by Cell Press in the September 8 issue of the journal Neuron identifies a previously unrecognized link between neuroinflammation and the classical pathological brain changes that are the hallmark of the disease. In addition, the research identifies a new potential therapeutic target for AD. AD is characterized by abnormal accumulation...

2011-09-06 22:12:06

Study reveals that insulin-stimulated glucose uptake–a process that breaks down in type 2 diabetes–requires a previously unidentified protein called CDP138 All cells need glucose (sugar) to produce the energy they need to survive. High glucose levels in the bloodstream (such as occur after a meal), trigger the pancreas to produce insulin. In turn, muscle and fat cells respond to insulin by moving GLUT4, a glucose transporter, from intracellular storage out to the cell surface....

2011-09-01 16:37:55

Alzheimer disease (AD) is the most common cause of dementia among older people. One of the main features of AD is the presence in the brain of abnormal clumps of the protein fragment beta-amyloid, which are known as amyloid plaques. A team of researchers, led by Jens Pahnke, at the University of Rostock, Germany, has now identified a way to reduce the amount of beta-amyloid in the brains of mice with a disease that models AD, providing hope that a similar approach might be possible in...

2011-09-01 15:24:41

Researchers have found that a protein variation linked by some genetic studies to Alzheimer's disease is consistently present in the brains of people with Alzheimer's. In further biochemical and cell culture investigations, they have shown that this protein, known as ubiquilin-1, performs a critical Alzheimer's-related function: it "chaperones" the formation of amyloid precursor protein, a molecule whose malformation has been directly tied to Alzheimer's pathology. "What we saw here is...

2011-08-30 11:12:55

A gene that governs the flow of potassium in and out of cells in blood vessels could provide a new avenue for controlling blood pressure, said researchers from Baylor College of Medicine in a report in the current issue of the journal Hypertension. The gene, known as K2P6.1 or TWIK-2, is one of a family of potassium channel genes first discovered in the 1990s. In general, ion channels are tiny pores that, when opened, allow charged ions such as sodium, potassium or calcium to flow in and...

2011-08-29 12:04:04

Preventing the formation of amyloid fibrils A molecule which can stop the formation of long protein strands, known as amyloid fibrils, that cause joint pain in kidney dialysis patients has been identified by researchers at the University of Leeds. The discovery could lead to new methods to identify drugs to prevent, treat or halt the progression of other conditions in which amyloid fibrils play a part, including Alzheimer's, Parkinson's and Type II diabetes. The research, funded by...

2011-08-16 21:13:09

As the gatekeepers of ion flow through cell membranes, ion channels are of key interest in numerous cellular processes. Now, a new study describes an innovative new computational model that realistically simulates the complex conditions found in biological systems and allows for a more accurate look at ion channel function at the level of individual atoms. The research, published by Cell Press in the August 17th issue of the Biophysical Journal, provides a remarkably detailed look at the...


Word of the Day
holluschickie
  • A 'bachelor seal'; a young male seal which is prevented from mating by its herd's older males (mated bulls defending their territory).
This comes from the Russian word for 'bachelors.'
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