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Latest Integral membrane proteins Stories

2013-07-16 15:42:18

Brandeis scientists bring us a step closer to understanding how to control cancer cells without harming healthy ones The nasty side effects of radiation and chemotherapy are well known: fatigue, hair loss and nausea, to name a few. Cancer treatment can seem as harsh as the disease because it can't differentiate healthy cells from cancerous cells, killing both. But what if there were a way to control or stop the growth of cancer cells without harming other cells? Brandeis biologist...

2013-07-16 08:30:19

BOSTON, July 16, 2013 /PRNewswire-USNewswire/ -- Additional analyses from a negative Phase 3 clinical trial of IVIG (intravenous immunoglobulin) in people with mild to moderate Alzheimer's disease were reported today at the Alzheimer's Association International Conference® 2013 (AAIC® 2013) in Boston. "We learn more about Alzheimer's disease from every study," said Maria Carrillo, Ph.D., Alzheimer's Association vice president of Medical and Scientific Relations. "Even negative...

2013-07-12 12:25:54

BOSTON, July 12, 2013 /PRNewswire-USNewswire/ -- Three studies reported at the Alzheimer's Association International Conference® 2013 (AAIC® 2013) demonstrate the vitality and diversity of Alzheimer's disease research being conducted in Boston, the host city for this year's conference. The three research reports cover: Early-stage drug development for new compounds to reduce beta-amyloid. Identifying genes that impact the rate of decline in Alzheimer's disease. Early...

2013-07-08 12:09:26

UConn researchers shed new light on how cellular transport systems harness energy to perform their work inside the cell Using highly sensitive fluorescent probes, a team of scientists from the University of Connecticut has captured the never-before-seen structural dynamics of an important protein channel inside the cell's primary power plant – the mitochondrion. The UConn team's study found that the channel complex - known as the translocase of the inner mitochondrial...

Tiny Molecule May Help Treat Alzheimers
2013-06-27 12:23:53

Brett Smith for redOrbit.com - Your Universe Online Researchers at Northwestern University say they have been working with a promising new drug-like molecule that could lead to a preventative treatment for Alzheimer's disease, according to their report in the open access journal PLOS ONE. "This is the starting point for the development of a new class of drugs," said lead researcher D. Martin Watterson, a professor molecular biology and biochemistry at Northwestern. "It's possible...

2013-06-24 10:37:13

Researchers in Berlin and Munich, Germany and Oxford, United Kingdom, have revealed that a protein well known for its role in Alzheimer's disease controls spindle development in muscle and leads to impaired movement in mice when the protein is absent or treated with inhibitors. The results, which are published in The EMBO Journal, suggest that drugs under development to target the beta-secretase-1 protein, which may be potential treatments for Alzheimer's disease, might produce unwanted side...

Alzheimer's Disease Drug Stopped Mid-Trial
2013-06-17 05:08:38

Lee Rannals for redOrbit.com - Your Universe Online Eli Lilly & Co has ended a clinical trial for an Alzheimer's disease drug during the middle of the study after patients showed abnormal liver biochemical tests. The company announced last week that it would be putting a halt to its LY2886721 drug trial. LY2886721, the code-name for the drug, was designed to inhibit beta secretase, which contributes to the buildup of amyloid plaque in the brain that is believed to cause Alzheimer's....

2013-06-13 16:27:02

Decision does not impact other Lilly Alzheimer's compounds in development INDIANAPOLIS, June 13, 2013 /PRNewswire/ -- Eli Lilly and Company (NYSE: LLY) today announced it has stopped its Phase II study (BACC) for LY2886721, a beta secretase (BACE) inhibitor being investigated as a once daily treatment for its potential to slow the progression of Alzheimer's disease. The decision to terminate the study was due to abnormal liver biochemical tests. Clinical study investigators have...

2013-06-13 10:06:12

Mount Sinai researchers find reduction in brain plaques in mice after treatment with drugs currently prescribed for other indications Multiple drug classes commonly prescribed for common medical conditions are capable of influencing the onset and progression of Alzheimer's disease, according to researchers at The Mount Sinai Medical Center. The findings are published online in the journal PLoS One. Led by Giulio Maria Pasinetti, MD, PhD, the Saunders Family Chair and Professor in...

Researchers Quantify Brain Protein Changes In Alzheimer Patients
2013-06-13 08:30:44

April Flowers for redOrbit.com - Your Universe Online A significant and potentially pivotal difference between the brains of patients with an inherited form of Alzheimer's disease and healthy family members who do not have it has been measured by researchers at Washington University School of Medicine in St. Louis. Researchers have long known that a protein fragment called amyloid beta builds up into plaques in Alzheimer´s patient´s brains. The theory is that these plaques...