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Latest Interleukin 12 Stories

2012-10-15 16:31:08

Psoriasis is a chronic inflammatory skin disorder that affects approximately 2% of the world's population. A group of inflammatory molecules known as interleukins activate an immune response that causes itchy skin, but it is unclear how the skin cells and immune cells communicate. In a study published in the Journal of Clinical Investigation, researchers led by Manfred Kopf at the Swiss Federal Institute of Technology in Zürich, Switzerland found that mice lacking...

2012-06-11 20:07:02

The human immune system has a natural ability to identify and attack tumor cells. Natural killer (NK) cells are innate immune cells that are particularly effective at killing tumor cells due to their ability to secrete cytotoxic enzymes. However, mutations have allowed many types of tumors to develop a resistance to NK-mediated killing through ill-defined mechanisms. Dr. Jerome Ritz and colleagues at the Dana-Farber Cancer Institute in Boston sought to pinpoint some of these mechanisms using...

2012-05-09 19:24:23

Rather than stimulating immune cells to more effectively battle cancerous tumors, treatment with the protein interleukin-12 (IL-12) has the opposite effect, driving these intracellular fighters to exhaustion, a Mayo Clinic study has found. The findings appear in the Journal of Clinical Investigation. The study helps explain the negative results of clinical trials testing the treatment's ability to ramp up the body's natural immune response to destroy cancer cells. The study also demonstrates...

2011-05-10 15:37:08

Researchers with UCLA's Jonsson Comprehensive Cancer Center have discovered a way to amp up the power of killer T-cells, called CD8 cells, making them more functional for longer periods of time and boosting their ability to multiply and expand within the body to fight melanoma, a new study has found. The study, done in mouse models of metastatic melanoma that had spread to the brain, has important clinical implications, as the method could boost the cancer-killing power of experimental...

2010-01-20 17:25:03

WHAT: A new study in human cells has singled out a molecule that specifically directs immune cells to develop the capability to produce an allergic response. The signaling molecule, called thymic stromal lymphopoietin (TSLP), is key to the development of allergic diseases such as asthma, atopic dermatitis (eczema), and food allergy. The study team, led by Yong-Jun Liu, M.D., Ph.D., at the University of Texas M.D. Anderson Cancer Center, Houston, focused on dendritic cells, immune cells that...

2009-09-15 12:00:40

British scientists say they've identified the master gene that causes blood stem cells to turn into disease-fighting immune cells. Imperial College London researchers say their finding could help scientists boost the body's production of tumor-killing cells, creating new ways to treat cancer. The researchers said they 'knocked out' the gene in question, known as E4bp4, in a mouse model, thereby creating the world's first animal model entirely lacking so-called natural killer cells, but with...

2009-01-21 13:17:21

Canadian medical researchers say they have discovered a new anti-cancer, anti-infection response control mechanism. Dr. Andre Veillette of the Institute of Research Clinics in Montreal, and his team led by postdoctoral fellow Dr. Mario-Ernesto Cruz-Munoz, said their discovery could have a significant impact on the treatment of cancers and infectious diseases. The team identified one of the basic mechanisms controlling natural killer cell activity. Produced by the immune system, NK cells are...


Word of the Day
negawatt
  • A unit of saved energy.
Coined by Amory Lovins, chairman of the Rocky Mountain Institute as a contraction of negative watt on the model of similar compounds like megawatt.