Latest Intron Stories
Using a new approach to studying the spliceosome, a team led by University of Michigan chemistry and biophysics professor Nils Walter, collaborating closely with a team led by internationally recognized splicing experts John Abelson and Christine Guthrie of the University of California, San Francisco, spied on the splicing process in single molecules.
TAU researchers unravel the mysteries of DNA packaging.
The sequences of nonsense DNA that interrupt genes could be far more important to the evolution of genomes than previously thought.
A chemical cousin of the common antibiotic tetracycline might be useful in treating spinal muscular atrophy (SMA), a currently incurable disease that is the leading genetic cause of death in infants.
Two molecular biologists at Cold Spring Harbor Laboratory have uncovered important new details about how a gene mutation causes a cellular editing error that results in a devastating disease called pontocerebellar hypoplasia (PCH).
An international research team led by Tim Nilsen, Ph.D., a professor of medicine and biochemistry and the director of the School of Medicine's Center for RNA Molecular Biology, has discovered an unexpected mechanism governing alternative splicing, the process by which single genes produce different proteins in different situations. The new mechanism suggests that curing the more than half of genetic diseases that are caused by mutations in the genetic code that in turn create mistakes in...
By Ponomarev, Vladimir Recent years have witnessed a remarkable increase in our knowledge and understanding of the genetics and molecular biology of human diseases. During the past 2 decades, technologic innovations revolutionized molecular and cell biology.
Splicing exerts selective pressure on DNA sequence
The discovery in 1977 that the coding regions of a gene could appear in separate segments along the DNA won the 1993 Nobel Prize in Physiology or Medicine for Richard J. Roberts and Phillip A. Sharp. The active segments of a gene were termed exons, separated from each other within the gene by inactive introns.
Important messages require accurate transmission. Big genes are especially challenging because they combine many coding segments (exons) that lie between long stretches of non-coding elements (introns).
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