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Latest Ion channels Stories

2014-03-05 10:36:54

After a decade of debate, scientists have a clear picture of a controversial protein that helps regulate heart contractions Brandeis University researchers have unlocked a controversial structure in heart cells responsible for regulating heart contractions. For years, scientists have debated how many KCNE1 proteins are required to build a potassium ion channel, theorizing anywhere between one and 14. Now, Brandeis University researchers found that these channels are built with two E1s....

New Findings Could Lead To Novel Diagnostic Tests And Treatments For Male Infertility
2014-02-19 10:38:25

American Institute of Physics To better understand the causes of male infertility, a team of Bay Area researchers is exploring the factors, both physiological and biochemical, that differentiate fertile sperm from infertile sperm. At the 58th Annual Biophysical Society Meeting, which takes place Feb. 15-19, 2014, in San Francisco, Calif., the team will present its work to identify and characterize proteins known as ion channels, which are crucial for sperm fertility and expressed within a...

2013-12-05 23:40:35

The N-methyl-D-aspartic acid (NMDA) receptor dysfunction in the brain of aged animals has been shown. In older rodents, N-methyl-D-aspartate receptor 2B subunit gene expression declines significantly associated with memory impairment. To further reveal this process, Dr. Chunxia Li and colleagues from East China Normal University, China analyzed gene expression profiles in the neocortex of aged Tg mice. Pathway and signal-net analyses identified multiple pathways altered in the transgenic...

2013-11-26 15:05:56

Researchers from the University of Southampton, in collaboration with researchers at the University of Quebec at Montreal, have developed a new microsystem for more efficient testing of pharmaceutical drugs to treat diseases such as cystic fibrosis, MG (myasthenia gravis) and epilepsy. A large percentage of pharmaceutical drugs target ion channels, which are proteins found in a cell's membrane, that play a pivotal role in these serious disorders and that are used to test the effectiveness...

2013-11-25 09:57:46

Filtered from a vast sodium sea, more than 1 million calcium ions per second gush through our cells' pores to generate charges Scientists have figured out how calcium channels – the infinitesimal cell membrane pores that generate electrical signals by gating a charged-particle influx – have solved a "needle in a haystack" problem. The solution to the longstanding riddle is reported in the Nov. 24 advanced online edition of Nature by University of Washington and Howard Hughes Medical...

2013-10-30 11:07:26

A crucial component of wound healing in many animals, including humans, is the migration of nearby skin cells toward the center of the wound. These cells fill the wound in and help prevent infection while new skin cells regenerate. How do these neighboring skin cells know which way to migrate? What directional cues are they receiving from the wound site? A new paper by Mark Messerli and David Graham of the MBL’s Eugene Bell Center for Regenerative Biology and Tissue Engineering clarifies...

2013-10-07 13:50:24

This press release is in support of a presentation by Dr. Benoit Delatour on Monday Oct. 7 at the 26th ECNP Congress in Barcelona, Spain A selective GABA inverse agonist has restored cognitive function in a mouse model of Down's syndrome (DS) and has the potential to benefit humans, French researchers have revealed. "The drug we used is a specific GABA-A α5 inverse agonist (α5IA) that hypothetically could combat the abnormal neuronal excitation/inhibition balance associated with DS",...

2013-10-07 13:16:40

This press release is in support of a presentation by Professor Gerard Sanacora on Sunday Oct. 6 at the 26th ECNP Congress in Barcelona, Spain Glutamergic agents may one day be used as a novel treatment for mood and anxiety disorders, new research presented at the 26th ECNP Congress suggests. "Our results suggest the glutamatergic system is a truly viable target for antidepressant Profug development," says Professor Gerard Sanacora, from the Yale School of Medicine, Connecticut, US....

Propofol Breakthrough New Anesthetics
2013-09-23 09:33:59

Brett Smith for redOrbit.com - Your Universe Online New research from an international team of scientists has revealed the specific chemical mechanism behind the anesthetic propofol, the drug widely known for being implicated in the death of music icon Michael Jackson. According to a report published in the journal Nature Chemical Biology, the international team located the specific site on the brain where propofol binds to receptors and sedates patients before surgery. "For many...


Word of the Day
negawatt
  • A unit of saved energy.
Coined by Amory Lovins, chairman of the Rocky Mountain Institute as a contraction of negative watt on the model of similar compounds like megawatt.