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Latest Ion channels Stories

2013-12-05 23:40:35

The N-methyl-D-aspartic acid (NMDA) receptor dysfunction in the brain of aged animals has been shown. In older rodents, N-methyl-D-aspartate receptor 2B subunit gene expression declines significantly associated with memory impairment. To further reveal this process, Dr. Chunxia Li and colleagues from East China Normal University, China analyzed gene expression profiles in the neocortex of aged Tg mice. Pathway and signal-net analyses identified multiple pathways altered in the transgenic...

2013-11-26 15:05:56

Researchers from the University of Southampton, in collaboration with researchers at the University of Quebec at Montreal, have developed a new microsystem for more efficient testing of pharmaceutical drugs to treat diseases such as cystic fibrosis, MG (myasthenia gravis) and epilepsy. A large percentage of pharmaceutical drugs target ion channels, which are proteins found in a cell's membrane, that play a pivotal role in these serious disorders and that are used to test the effectiveness...

2013-11-25 09:57:46

Filtered from a vast sodium sea, more than 1 million calcium ions per second gush through our cells' pores to generate charges Scientists have figured out how calcium channels – the infinitesimal cell membrane pores that generate electrical signals by gating a charged-particle influx – have solved a "needle in a haystack" problem. The solution to the longstanding riddle is reported in the Nov. 24 advanced online edition of Nature by University of Washington and Howard Hughes Medical...

2013-10-30 11:07:26

A crucial component of wound healing in many animals, including humans, is the migration of nearby skin cells toward the center of the wound. These cells fill the wound in and help prevent infection while new skin cells regenerate. How do these neighboring skin cells know which way to migrate? What directional cues are they receiving from the wound site? A new paper by Mark Messerli and David Graham of the MBL’s Eugene Bell Center for Regenerative Biology and Tissue Engineering clarifies...

2013-10-07 13:50:24

This press release is in support of a presentation by Dr. Benoit Delatour on Monday Oct. 7 at the 26th ECNP Congress in Barcelona, Spain A selective GABA inverse agonist has restored cognitive function in a mouse model of Down's syndrome (DS) and has the potential to benefit humans, French researchers have revealed. "The drug we used is a specific GABA-A α5 inverse agonist (α5IA) that hypothetically could combat the abnormal neuronal excitation/inhibition balance associated with DS",...

2013-10-07 13:16:40

This press release is in support of a presentation by Professor Gerard Sanacora on Sunday Oct. 6 at the 26th ECNP Congress in Barcelona, Spain Glutamergic agents may one day be used as a novel treatment for mood and anxiety disorders, new research presented at the 26th ECNP Congress suggests. "Our results suggest the glutamatergic system is a truly viable target for antidepressant Profug development," says Professor Gerard Sanacora, from the Yale School of Medicine, Connecticut, US....

Propofol Breakthrough New Anesthetics
2013-09-23 09:33:59

Brett Smith for redOrbit.com - Your Universe Online New research from an international team of scientists has revealed the specific chemical mechanism behind the anesthetic propofol, the drug widely known for being implicated in the death of music icon Michael Jackson. According to a report published in the journal Nature Chemical Biology, the international team located the specific site on the brain where propofol binds to receptors and sedates patients before surgery. "For many...

Water Molecules Control Long Post-activation Recovery Period Of Potassium Channels
2013-07-29 08:51:57

University of Chicago Medical Center Just 12 molecules of water cause the long post-activation recovery period required by potassium ion channels before they can function again. Using molecular simulations that modeled a potassium channel and its immediate cellular environment, atom for atom, University of Chicago scientists have revealed this new mechanism in the function of a nearly universal biological structure, with implications ranging from fundamental biology to the design of...

2013-05-29 09:48:10

For several years, the pharmaceutical industry has tried to develop drugs that target a specific neurotransmitter receptor in the brain, the NMDA receptor. This receptor is present on almost every neuron in the human brain and is involved in learning and memory. NMDA receptors also have been implicated in several neurological and psychiatric conditions such as Alzheimer's disease, Parkinson's disease, schizophrenia and depression. But drug companies have had little success developing...

2013-05-24 23:20:39

“The Sodium Theory Revisited” reveals newest developments in nerve function research. UNITED KINGDOM (PRWEB) May 24, 2013 The sodium theory has been elegantly proposed by A.L. Hodkin, A.F. Huxley and B. Katz in the early 1950s, after their experiments on Plymouth squids, to account for the role of sodium and potassium ions in nerve functions. Since then, the electrophysiological techniques and the data acquisition techniques have known amazing developments. In The Sodium Theory...


Word of the Day
glogg
  • Scandinavian punch made of claret and aquavit with spices and raisins and orange peel and sugar.
This word comes from the Swedish 'glogg,' which is an alteration of 'glodgat,' mulled (wine).
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