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Latest Ion channels Stories

2011-06-16 13:21:10

Precisely mapped allosteric binding site will facilitate design of drugs with minimal side effects Structural biologists at Cold Spring Harbor Laboratory (CSHL) have obtained a precise molecular map of the binding site for an allosteric inhibitor in a subtype of the NMDA (N-methyl-D-aspartate) receptor, which is commonly expressed in brain cells. The newly discovered binding site -- a docking port within the receptor -- is important because it is a potential target for drugs that can modulate...

2011-06-16 07:00:00

SAN MATEO, Calif., June 16, 2011 /PRNewswire/ -- NeurogesX, Inc. (Nasdaq: NGSX), a biopharmaceutical company focused on developing and commercializing novel pain management therapies, today announced the completion of patient enrollment in its Phase 2 clinical study of NGX-1998, a topical liquid formulation of high-concentration capsaicin, in patients with postherpetic neuralgia (PHN). NGX-1998 is being developed to provide safety, efficacy and tolerability that is at least comparable to...

2011-04-28 07:00:00

SAN MATEO, Calif., April 28, 2011 /PRNewswire/ -- NeurogesX, Inc. (Nasdaq: NGSX), a biopharmaceutical company focused on developing and commercializing novel pain management therapies, today announced that it has received a Notice of Allowance from the U.S. Patent and Trademark Office for its patent entitled, "Methods and Compositions for Administration of TRPV1 Agonists." The allowed claims include method of use, formulation and system claims. The patent scheduled to issue from this...

2011-04-27 13:24:11

Research at Children's National uncovers an unknown side effect of a promising drug for acute chronic pain Pain researchers from the Sheikh Zayed Institute for Pediatric Surgical Innovation at Children's National Medical Center have discovered that resiniferatoxin, a drug that has shown early promise as an option for chronic, severe pain sufferers, may decrease the body's ability to fight off bacterial infections, particularly sepsis. The study, which appears in the May 1 edition of the...

2011-04-26 23:32:16

Structure of GluN2D subunit when docked with certain neurotransmitters helps explain the receptor's slow deactivation Structural biologists at Cold Spring Harbor Laboratory (CSHL) in collaboration with colleagues at Emory University have determined the molecular structure of a key portion, or subunit, of a receptor type commonly expressed in brain cells. The receptor is one of several NMDA (N-methyl-D-aspartate) receptor variants, and the subunit in question is that which specifically binds...

2011-04-25 14:52:06

The latest Perspectives in General Physiology series examines the ion selectivity of cation-selective channels and transporters. The series appears in the May 2011 issue of the Journal of General Physiology (www.jgp.org). According to Perspectives Editor Olaf Andersen in his introduction, a key tool in most recent studies on ion selectivity has been the so-called "toy models," which emphasize the fluid-like features of the selectivity filter and allow for the isolation of key features....

2011-04-08 13:28:48

Functional change ('modal shift') of the TRP channel through evolution The animals on the earth have adapted themselves to the environmental temperature changes such as hot in deserts, or cold in the glacial epochs. However, the molecular mechanism for adaptation to thermal environments in the evolutionary process involving temperature sensors was not well understood. Professor Makoto Tominaga and Assistant Professor Shigeru Saito at The National Institute for Physiological Sciences (Okazaki...

2011-03-24 07:00:00

SUNNYVALE, Calif., March 24, 2011 /PRNewswire/ -- Molecular Devices, Inc. and ChanTest Corporation, leading providers of ion channel and GPCR drug discovery tools and solutions, have signed an agreement for Molecular Devices to distribute ChanTest's extensive portfolio of ion channel and GPCR cell lines on a non-exclusive basis. As part of the agreement, Molecular Devices, Inc. will sell ChanTest's ion channel and GPCR cell lines and promote ChanTest's cell optimization services to its...

2011-03-22 12:50:30

A key question in protein biochemistry is how proteins recognize "correct" interaction partners in a sea of cellular factors. Nowhere is that more critical to know than in the brain, where interactions governing channel protein activity can alter an organism's behavior. A team of biologists at the Salk Institute for Biological Studies has recently deciphered a molecular code that regulates availability of a brain channel that modulates neuronal excitability, a discovery that might aid efforts...

2011-03-10 23:26:21

A light-sensing receptor that's packed inside the eye's photoreceptor cells has an altogether surprising role in cells elsewhere in the body, Johns Hopkins scientists have discovered. Using fruit flies, they showed that this protein, called rhodopsin, also is critical for sensing temperature. A report on the work appears March 11 in Science. "For decades, this well-known molecule "” one of the most-studied sensory receptors "” was thought to function exclusively in the eye as a...


Word of the Day
barratry
  • The offense of persistently instigating lawsuits, typically groundless ones.
  • An unlawful breach of duty on the part of a ship's master or crew resulting in injury to the ship's owner.
  • Sale or purchase of positions in church or state.
This word ultimately comes from the Old French word 'barater,' to cheat.
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