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Latest Ion channels Stories

2011-02-02 01:16:50

Research by a Barrow Neurological Institute scientist on the thermoregulatory effects of a receptor more commonly studied for its role in pain is the cover story in the Feb. 2 issue of the Journal of Neuroscience. The research was conducted by an international team led by Andrej Romanovsky, MD, PhD, Director of the Systemic Inflammation Laboratory (FeverLab), at Barrow, which is a part of St. Joseph's Hospital and Medical Center. The featured research discovers a new role of TRPV1 (transient...

2011-01-28 12:39:39

Australian researchers have come one step closer to understanding how the rhythm of the heartbeat is controlled and why many common drugs, including some antibiotics, antihistamines and anti-psychotics, can cause a potentially fatal abnormal heart rhythm. It is estimated around 40-50% of all drugs in development will block one of the main "Ëœchannels' that carries electricity in the heart and, as a result, can cause heart rhythm problems called cardiac arrhythmias. Most sudden...

2011-01-26 20:31:32

Pressor reflex triggered simply by drinking water For 60 years, scientists have puzzled over the possibility of a hepatic osmoreceptor that influences blood pressure regulation. Now, researchers of the Max Delbrck Center for Molecular Medicine (MDC) Berlin-Buch, the Experimental and Clinical Research Center (ECRC) of the MDC and Charit© and the Hannover Medical School (MHH) appear to have made a breakthrough discovery. Dr. Stefan Lechner and Professor Gary R. Lewin (both of MDC),...

2011-01-26 13:09:34

New finding adds significantly to our understanding of calcium channel function in health and disease Scientists in the Hotchkiss Brain Institute at the Faculty of Medicine, University of Calgary, have discovered a new mechanism that nerve cells (neurons) use to fine-tune their electrical output. The exciting discovery, published this week in the prestigious journal Nature Neuroscience, provides new insights about how the activity of the nervous system is regulated at the cellular level....

2011-01-19 13:20:39

Combination of sensory and molecular approaches identify receptor sensitive to anti-inflammatory compounds Scientists from the Monell Center and collaborators report that a receptor known as TRPA1 is activated by two structurally unrelated anti-inflammatory compounds. The first, oleocanthal, is a natural polyphenolic anti-inflammatory agent uniquely found in extra virgin olive oil; while the second, ibuprofen, is an over-the-counter non-steroidal anti-inflammatory drug (NSAID). The...

2011-01-11 14:36:29

Smoking is a common problem for patients with schizophrenia. The increased tendency of patients diagnosed with this disorder is to not only smoke, but to do so more heavily than the general public. This raises the possibility that nicotine may be acting as a treatment for some symptoms of schizophrenia. Nicotine acts through two general classes of brain receptors, those with high and low affinity for nicotine. The low affinity class of nicotinic receptors contains the alpha-7 subunit, which...

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2010-12-15 07:46:02

They say it's the little things that count, and that certainly holds true for the channels in transmembrane proteins, which are small enough to allow ions or molecules of a certain size to pass through, while keeping out larger objects. Artificial fluidic nanochannels that mimic the capabilities of transmembrane proteins are highly prized for a number of advanced technologies. However, it has been difficult to make individual artificial channels of this size "“ until now. Researchers...

2010-12-13 21:10:37

Researchers have provided the first thorough mechanistic account of how a genetic defect leads to malignant hypothermia (MH) and central core disease (CCD), rare genetic skeletal muscle disorders. The study appears in the January issue of the Journal of General Physiology (www.jgp.org). Mutations in the type 1 ryanodine receptor (RYR1), the calcium release channel of the sarcoplasmic reticulum (SR) activated during skeletal muscle excitation-contraction (EC) coupling, give rise to CCD. One of...

2010-11-15 12:12:44

Researchers at the University of North Carolina at Chapel Hill School of Medicine have demonstrated that the gene mutated in cystic fibrosis not only controls traffic on the chloride highway, but also keeps the sodium highway from being overused. An imbalance of salt and water in patients with cystic fibrosis makes their lungs clog up with sticky mucus that is prone to infection. The cause of the offending imbalance is a well-known genetic error, one that blocks the molecular expressway for...

2010-11-05 09:00:00

WATERTOWN, Mass., Nov. 5, 2010 /PRNewswire/ -- EnVivo Pharmaceuticals today announced it has discovered that EVP-6124, its alpha-7 nicotinic acetylcholine receptor agonist, possesses a novel mechanism not previously seen in the scientific community: it acts as a co-agonist with Acetylcholine (ACh) to enhance cognition. By acting as a co-agonist and sensitizing the alpha-7 receptor, EVP-6124 makes it possible for smaller amounts of naturally occurring ACh, typically found in individuals...


Word of the Day
glogg
  • Scandinavian punch made of claret and aquavit with spices and raisins and orange peel and sugar.
This word comes from the Swedish 'glogg,' which is an alteration of 'glodgat,' mulled (wine).
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