Latest Ischemia Stories

2012-02-01 14:32:19

Source of damage to donor organs identified For patients with incurable pulmonary conditions, a lung transplantation is the only available treatment option. However, suitable donor organs are scarce, and even getting them to prospective recipients is not easy. As Professor Alexander Dietrich of the Walther Straub Institute of Pharmacology and Toxicology at LMU explains, “An isolated lung which is no longer perfused with blood can become so severely damaged that it is no longer...

2011-12-28 07:51:30

For patients admitted to an emergency department with chest pain, use of a contemporary or highly sensitive test for levels of troponin I (a protein in muscle tissue) may help rule-out a diagnosis of heart attack, while changes in the measured levels of this biomarker at 3 hours after admission may be useful to confirm a diagnosis of heart attack, according to a study in the December 28 issue of JAMA. One of the most common reasons patients seek care in an emergency department is for acute...

2011-12-01 01:12:17

The ambivalent role of the CXCL12/ CXCR4 axis in heart repair The chemokine CXCL12 acts as a chemical signal which mobilizes hematopoietic and other types of stem cells to leave the bone marrow and enter the circulation. Secretion of CXCL12 also guides these cells to sites at which the perfusion of tissue is sub-optimal due to localized obstruction of blood flow. These capabilities have made CXCL12 and its cognate receptor CXCR4 interesting candidates for therapies aimed at mitigating the...

Damage From Heart Attack Dependent On Time Of Day
2011-11-22 06:20:41

In a first of its kind study, researchers have discovered  that the size of a heart attack and the remaining left-ventricular function that follows depends on the time of day that ischemia in the heart occurs. They found the greatest amount of damage happens when a heart attack occurs between 1:00 am and 5:00 am. Researchers had previously discovered that the amount of tissue death and the return of the blood supply to the heart exhibited a circadian dependence in rats. It was unknown...

2011-11-18 02:52:23

Reducing a protein called Siah2 in mice improves mitochondrial response to low oxygen, a condition cells experience when blood flow is restricted during a heart attack Mitochondria are often called cellular "powerhouses" because they convert nutrients into energy. But these tiny structures also help determine cellular lifespan. Scientists at Sanford-Burnham Medical Research Institute (Sanford-Burnham) are now discovering how mitochondria alternate between duplicating and fragmenting and...

2011-10-11 13:46:48

Bypassing the occlusion Mazzone has demonstrated that arteriogenesis (growth of pre-existing connections between distinct blood vessels into functional arteries) can be accelerated by blocking the function of the protein PhD2 in a particular class of white blood cells. This resulted in wider and functional vessels, which allows the blood to bypass the occlusion and thus offers better blood perfusion. The scientists want to investigate in further detail the therapeutic potential of blocking...

Word of the Day
  • In the phrase to out-herod Herod, to be more violent than Herod (as represented in the old mystery plays); hence, to exceed in any excess of evil.
Herod refers to 'Herod the Great,' a Roman client king and 'a madman who murdered his own family and a great many rabbis.' According to the OED, the term is 'chiefly with allusion to Shakespeare's use' in Hamlet.