Quantcast

Latest Isoniazid Stories

2011-03-03 23:12:18

Inexpensive drugs already approved for other uses can block tolerance mechanism New findings on how tuberculosis (TB) bacteria develop multi-drug tolerance point to ways TB infections might be cured more quickly. The study will be published April 1 in the journal Cell. The results identify both a mechanism and a potential therapy for drug tolerance that is induced in the TB bacteria by the host cells they infect. Currently, TB treatment requires a complex, long-term curative regimen of at...

2010-11-29 14:30:43

A team of researchers from Spain and Latin America have synthesized two iron compounds that inhibit the in vitro growth of Mycobacterium tuberculosis, the bacteria that causes tuberculosis. Due their low level of toxicity in mammel cells, the compounds could be used in the future as therapeutic agents and hospital disinfectants. A group of researchers from the Universidad de Navarra (Spain), the Universidad de la República (Uruguay), the Universidad de...

2010-11-17 13:27:35

A key enzyme in Mycobacterium tuberculosis that enables the microbe to reproduce rapidly could be a golden target for new drugs against tuberculosis (TB), according to a study published in Microbiology on 17 November. The human equivalent of this enzyme has been targeted in some cancer treatments as well as in immunosuppressive chemotherapies. Scientists at the University of Birmingham have now shown that inhibiting the same enzyme in M. tuberculosis effectively kills the bacterial cells. The...

2010-03-30 13:58:06

DALLAS -- Two new tuberculosis studies by UT Southwestern Medical Center researchers provide good news and bad news about the bacterium that infects nearly a third of the world's population and a disease that kills nearly 2 million people each year. The good news: A type of blood pressure medication shows promise at overcoming some drug-resistant tuberculosis, at least in the laboratory. The bad news: The Mycobacterium tuberculosis bacterium, which causes the disease, might be resistant to...

fd833f00174f5caba7731a04e39d7c02
2010-03-04 14:15:00

By going 'back to the drawing board,' 2 teams advance on answers to TB epidemic When people get exposed to the mycobacterium responsible for tuberculosis (TB), some will become sick with a disease that is a major cause of mortality around the world while others simply don't. Now, researchers reporting in the March 5th issue of the journal Cell, a Cell Press publication, can point to one important reason for this variation in susceptibility or resistance: genetic differences among individuals...

2009-12-23 14:03:16

Scientists have identified a strain of antibiotic-resistant tuberculosis that thrives in the presence of rifampin, a front-line drug in the treatment of tuberculosis. The bacterium was identified in a patient in China and is described in a study by researchers at the Johns Hopkins Bloomberg School of Public Health, Chongqing Pulmonary Hospital, Lanzhou University and Fudan University. The researchers determined that the bacteria grew poorly in the absence of the antibiotic rifampin and better...

2009-11-07 06:00:00

MIAMI BEACH, Fla., Nov. 7 /PRNewswire/ -- Patients reported C1-esterase inhibitor (C1-INH) concentrate is an effective therapy in treating acute swelling attacks at any body location for HAE, a rare and serious genetic disorder, according to data presented today at the 2009 American College of Allergy, Asthma & Immunology (ACAAI) Annual Meeting. The results come from a self-reported survey of patients conducted in parallel with the ongoing, prospective, open label International...

2009-10-26 14:31:56

New TAU formulation may slow down Parkinson's, Alzheimer's and Huntington's diseases Working like an architect, Prof. Hagit Eldar-Finkelman of Tel Aviv University's Sackler School of Medicine is "building" a new drug, L803-MTS, to treat a number of central nervous system (CNS) diseases like Alzheimer's. In pre-clinical studies, it also shows promise against Parkinson's, Huntington's and diabetes. L803-MTS is based on the physical structure of the GSK3 protein, which plays a causative role in...

2009-09-15 07:55:05

International guidelines for treating tuberculosis are due for specific improvements, according to two research papers published this week in the open access journal PLoS Medicine. Public health programs in many countries adhere to World Health Organization (WHO) guidelines as the authoritative recommendations for treating tuberculosis (TB). But do these guidelines reflect the best available evidence? To answer this question, Dick Menzies of McGill University in Montreal and colleagues...

2009-06-03 16:00:00

Clinical Activity Of TMC207 shows ATP-Synthase is a Viable Target for treatment of TB MECHELEN, Belgium, June 3 /PRNewswire/ -- Interim results from an ongoing phase 2, randomized, placebo-controlled trial of the investigational drug TMC207 for the treatment of multidrug-resistant tuberculosis (MDR-TB) were published in the New England Journal of Medicine today. TMC207 is being developed by Tibotec BVBA. The data show that the addition of TMC207 for eight weeks to a 5-drug background...


Latest Isoniazid Reference Libraries

72_0ab04c9452ae9b3c6ae51f6deb1bcc35
2011-04-25 16:19:14

Mycobacterium tuberculosis (MTB) is a pathogenic bacterial species in the genus Mycobacterium and the causative agent of most cases of tuberculosis. Robert Koch first discovered it in 1882 and that it had an unusual, waxy coating on the cell surface which makes them impossible to Gram stain. M. tuberculosis is highly aerobic and requires high levels of oxygen. It generally infects the respiratory system of mammals. Tuberculin skin test, acid-fast stain, and chest radiographs are the most...

More Articles (1 articles) »
Word of the Day
tessitura
  • The prevailing range of a vocal or instrumental part, within which most of the tones lie.
This word is Italian in origin and comes from the Latin 'textura,' web, structure.