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Clinical Activity Of TMC207 shows ATP-Synthase is a Viable Target for treatment of TB MECHELEN, Belgium, June 3 /PRNewswire/ -- Interim results from an ongoing phase 2, randomized, placebo-controlled trial of the investigational drug TMC207 for the treatment of multidrug-resistant tuberculosis (MDR-TB) were published in the New England Journal of Medicine today.
New estimates of the likelihood that a latent case of tuberculosis (TB) will become active have resulted in a roughly 50 percent increase over previous estimates of the number of people needed to be screened (NNS) to prevent an active infection, limiting the cost effectiveness of screening in many Center for Disease Control and Prevention (CDC)-defined risk groups.
British medical scientists say the discovery of a large number of slow-growing Mycobacterium tuberculosis bacteria might lead to new anti-TB drugs. Until now it was thought that M. tuberculosis bacteria in the lungs of TB patients were rapidly multiplying.
The U.S. tuberculosis rate fell to an all-time low of 4.2 cases per 100,000 people, or 12,898 new cases, in 2008, federal health officials said.
A four-month treatment with the drug rifampin is better tolerated for tuberculosis than the nine-month treatment of isoniazid, Canadian researchers said. Dr.
MUHC researchers are studying a shorter treatment with fewer side effects.
The skeleton of a man discovered in a shallow grave on what is now a college campus in England could belong to one of Britain's earliest victims of tuberculosis. Radiocarbon dating suggests the man died in the fourth century, around A.D. 302, when Romans ruled the region.
Tuberculosis drug shows promise against latent bacteria WASHINGTON, Sept.
Aggressive treatment involving a combination of drugs may be the cure for extensively drug-resistant tuberculosis, researchers report.
Mycobacterium tuberculosis (MTB) is a pathogenic bacterial species in the genus Mycobacterium and the causative agent of most cases of tuberculosis. Robert Koch first discovered it in 1882 and that it had an unusual, waxy coating on the cell surface which makes them impossible to Gram stain. M. tuberculosis is highly aerobic and requires high levels of oxygen. It generally infects the respiratory system of mammals. Tuberculin skin test, acid-fast stain, and chest radiographs are the most...