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Latest Jason Sello Stories

2014-01-20 09:42:42

A new class of molecules called acyldepsipeptides — ADEPs — may provide a new way to attack bacteria that have developed resistance to antibiotics. Researchers at Brown and MIT have discovered a way to increase the potency of ADEPs by up to 1,200 times. Their findings appear in the Journal of the American Chemical Society. As concerns about bacterial resistance to antibiotics grow, researchers are racing to find new kinds of drugs to replace ones that are no longer effective. One...

2013-09-19 10:27:10

Mycobacterium tuberculosis, the bacterium that causes tuberculosis may have an Achilles’ heel: It needs a particular enzyme to survive. Inhibiting that enzyme’s function, researchers have shown, will kill the bacteria, pointing toward a design strategy for new TB drugs. To stay ahead in the race against drug-resistant infections, scientists constantly search for and exploit vulnerabilities in deadly bacteria. Now, researchers from Brown and the Massachusetts Institute of Technology...

2013-02-15 15:19:12

Digesting lignin, a highly stable polymer that accounts for up to a third of biomass, is a limiting step to producing a variety of biofuels. Researchers at Brown have figured out the microscopic chemical switch that allows Streptomyces bacteria to get to work, breaking lignin down into its constituent parts. Microorganisms that can break down plant biomass into the precursors of biodiesel or other commodity chemicals might one day be used to produce alternatives to petroleum. But the...

2011-11-28 23:11:01

Chemists at Brown University have synthesized a new compound that makes drug-resistant bacteria susceptible again to antibiotics. The compound – BU-005 – blocks pumps that a bacterium employs to expel an antibacterial agent called chloramphenicol. The team used a new and highly efficient method for the synthesis of BU-005 and other C-capped dipeptides. Results appear in Bioorganic and Medicinal Chemistry. It´s no wonder that medicine´s effort to combat bacterial...

2010-10-08 02:29:40

Two chemists at Brown University have streamlined the conversion of waste vegetable oil into biodiesel, eliminating the need for corrosive chemicals to perform the reactions. Writing in the journal Organic & Biomolecular Chemistry,  the chemists were able to pull off the waste vegetable oil-to-biodiesel conversion in a single reaction vessel using environmentally friendly catalysts and making the conversion six times faster than current methods. As the United States seeks to lessen...

2008-09-30 03:00:26

By Roach, Ronald The Leadership Alliance has produced more than 100 Ph.D.s, one- third of whom are now working in the academy. As a stellar student at Morehouse College in the 1990s, Dr. Jason Sello navigated a path to Harvard University where he earned a doctorate in biophysics. He credits his participation in the Brown University-based Leadership Alliance program for making it possible for him to conduct research alongside graduate students at the Harvard medical school during the summer...


Word of the Day
penuche
  • A fudgelike confection of brown sugar, cream or milk, and chopped nuts.
'Penuche' is a variant of 'panocha,' a coarse grade of sugar made in Mexico. 'Panocha' probably comes from the Spanish 'panoja, panocha,' ear of grain.
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