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Latest John Tainer Stories

2011-04-16 00:41:30

A Berkeley Lab-led team deciphers the structure of FEN1, a key player in DNA replication and repair DNA replication is critical to the life of all organisms, insuring that each new cell, as well as each new offspring, gets an accurate copy of the genome. Among the legions of proteins that do the work so essential to a cell's survival, the DNA-slicing "flap endonuclease" FEN1 plays a key role. The structure of human FEN1 has now been solved by an international team of scientists led by the...

2011-03-28 13:08:16

The discovery at Scripps Research could usher in a new way of designing non-toxic drugs, researchers say Over the last years, two teams of researchers at The Scripps Research Institute have steadily built a model of how a powerful DNA repair complex works. Now, their latest discovery provides revolutionary insights into the way the molecular motor inside the complex functions "“ findings they say may have implications for treatment of disorders ranging from cancer to cystic fibrosis. In...

2009-10-02 09:14:48

Understanding how serious breaks in DNA are repaired may help researchers to make cancer therapy more effective Researchers at The Scripps Research Institute have found, crystallized, and biologically characterized a poorly defined component of a key molecular complex that helps people to avoid cancer, but that also helps cancer cells resist chemotherapy. The research was published in the October 2, 2009 issue of the journal Cell. This biological machine"”the Mre11-Rad50-Nbs1 (MRN)...

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2009-07-21 09:39:42

Scientists at the U.S. Department of Energy's (DOE) Lawrence Berkeley National Laboratory have developed a fast and efficient way to determine the structure of proteins, shortening a process that often takes years into a matter of days. The high-throughput protein pipeline could allow scientists to expedite the development of biofuels, decipher how extremophiles thrive in conditions that kill most organisms, and better understand how proteins carry out life's vital functions. The technique...

2009-06-10 14:25:00

Proteins responsible for this type of DNA repair may also limit the effectiveness of chemotherapy agents, which aim to injure tumor DNAA team of researchers at The Scripps Research Institute and other institutions has discovered a new way by which DNA repairs itself, a process that is critical to the protection of the genome, and integral to prevention of cancer development.Scientists who study the repair of the DNA bases, which make up the information in the human genome, had known of only...


Word of the Day
abrosia
  • Wasting away as a result of abstinence from food.
The word 'abrosia' comes from a Greek roots meaning 'not' and 'eating'.