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Latest Jonathan Sebat Stories

Autism And Other Disorders May Be Caused By Genetic Hotspot Mutations
2012-12-21 06:47:01

[ Watch the Video: Mutation Hotspots in Autism Genes ] Connie K. Ho for redOrbit.com — Your Universe Online A group of international researchers led by a team of investigators from the School of Medicine at the University of California, San Diego (UCSD), recently revealed a new study that provides signals as to the causes of autism and other related disorders. With the findings, it is possible that there are elevated mutation rates in specific parts of the genome that adds to...

2011-02-24 20:46:36

A North Star amid 'a constellation of multiple rare diseases' Scientists are eyeing a rare genetic glitch for clues to improved treatments for some people with schizophrenia "“ even though they found the mutation in only one third of 1 percent of patients. In the study, funded in part by the National Institutes of Health, schizophrenia patients were 14 times more likely than controls to harbor multiple copies of a gene on Chromosome 7. The mutations were in the gene for VIPR2, the...

2011-02-08 07:55:10

(Ivanhoe Newswire) -- In a major advance for schizophrenia research, scientists identified a gene mutation linked to the severe brain disorder and a signaling pathway that could be treatable with existing methods. "In some ways, this is the kind of gene that the pharmaceutical industry has been waiting for," Jonathan Sebat, PhD, assistant professor of psychiatry and cellular and molecular medicine at the University of California, San Diego School of Medicine, was quoted as saying." Its...

2011-02-02 20:30:39

In a major advance for schizophrenia research, an international team of scientists, led by Jonathan Sebat, PhD, assistant professor of psychiatry and cellular and molecular medicine at the University of California, San Diego School of Medicine, has identified a gene mutation strongly linked to the brain disorder "“ and a signaling pathway that may be treatable with existing compounds. The work poses significant and immediate implications for neurobiology and the treatment of...

2009-10-26 15:05:31

Gene copy number variations of the same region, 16p11.2, are already linked to autism An international team of researchers led by geneticist Jonathan Sebat, Ph.D., of Cold Spring Harbor Laboratory (CSHL), has identified a mutation on human chromosome 16 that substantially increases risk for schizophrenia. The mutation in question is what scientists call a copy number variant (CNV). CNVs are areas of the genome where the number of copies of genes differs between individuals. The CNV is located...

2009-08-24 15:33:12

 A research team led by Associate Professor Jonathan Sebat, Ph.D., of Cold Spring Harbor Laboratory (CSHL) has developed a sensitive and accurate way of identifying gene copy number variations (CNVs). The method, which is described in a paper published online ahead of print in Genome Research, uses new DNA sequencing technologies to look for regions of the genome that vary in copy number between individuals in the population. Capable of detecting a wide range of different classes of...

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2008-03-31 09:30:00

Rare mutations disrupt genes in pathways of neuronal development and regulationUsing an important new method that can be applied in the study of other psychiatric illnesses, scientists at Cold Spring Harbor Laboratory (CSHL) in collaboration with colleagues at the University of Washington (UW) and the National Institute of Mental Health (NIMH), have identified multiple, individually rare gene mutations in people with schizophrenia that may help explain how that devastating illness is...


Word of the Day
malpais
  • The ragged surface of a lava-flow.
'Malpais' translates from Spanish as 'bad land.'