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Latest Kappa Opioid receptor Stories

2014-09-19 08:26:16

SAN FRANCISCO, Sept. 19, 2014 /PRNewswire/ -- Nektar Therapeutics (NASDAQ:NKTR) today announced results from preclinical studies characterizing the analgesic profiles of a series of the company's internally-discovered oral, peripherally-acting kappa opioid receptor agonist molecules. The preclinical research candidates were created using Nektar's small molecule polymer medicinal chemistry platform. The analgesic properties of kappa receptor agonism are well described in the medical...

2014-04-01 08:30:10

Rate of high risk use low among commercially insured ST. PAUL, Minn., April 1, 2014 /PRNewswire/ -- People who are at high-risk for opioid abuse use had significantly higher total medical costs ($19,513 vs. $5,493) than those who were not at high risk according to a new study by Prime Therapeutics (Prime). The Centers for Medicare & Medicare Services (CMS) defines high risk as "using a daily morphine equivalent dose (MED) of greater than 120 mg for at least 90 consecutive days,...

Scientists Solve Mystery Of How Sodium Controls Opioid Brain Signaling
2014-01-13 07:13:26

Scripps Research Institute The findings pave way for new therapies for treating pain and mood disorders Scientists have discovered how the element sodium influences the signaling of a major class of brain cell receptors, known as opioid receptors. The discovery, from The Scripps Research Institute (TSRI) and the University of North Carolina (UNC), suggests new therapeutic approaches to a host of brain-related medical conditions. "It opens the door to understanding opioid related...

2013-06-13 09:58:47

Scientists at The Scripps Research Institute (TSRI) have found evidence that an emotion-related brain region called the central amygdala–whose activity promotes feelings of malaise and unhappiness–plays a major role in sustaining cocaine addiction. In experiments with rats, the TSRI researchers found signs that cocaine-induced changes in this brain system contribute to anxiety-like behavior and other unpleasant symptoms of drug withdrawal–symptoms that typically drive an...

2013-03-07 11:22:19

In a new study in Neuron, scientists identified specific key steps in the chain of events that causes stress-related drug relapse. They identified the exact region of the brain where the events take place in rat models and showed that by blocking a step, they could prevent stress-related relapse. All too often, stress turns addiction recovery into relapse, but years of basic brain research have provided scientists with insight that might allow them develop a medicine to help. A new study...

Kicking Cocaine Addiction With A One-Two Punch
2012-08-09 10:56:41

Connie K. Ho for redOrbit.com — Your Universe Online Researchers from Scripps Research Institute recently revealed that a two-drug combination could possibly help those battling cocaine addiction. The combination made up of naltrexone and buprenoprine, two existing pharmaceutical drugs, is a therapy that would help reduce individuals´ want for cocaine and also lessen their feelings of withdrawal. Scientists believed that the therapy is a step forward as there are currently no...


Word of the Day
grass-comber
  • A landsman who is making his first voyage at sea; a novice who enters naval service from rural life.
According to the OED, a grass-comber is also 'a sailor's term for one who has been a farm-labourer.'