Quantcast

Latest Kinetochore Stories

2014-02-04 11:35:43

New insights into how the cells in our bodies divide could improve our knowledge of a condition linked to cancer, a study suggests. Errors in the cell division process – which allows us to grow and stay healthy – can lead to a genetic disorder called aneuploidy, which is also associated with birth defects and infertility. Researchers at the University of Edinburgh have pinpointed the key role played by a protein in ensuring that cells separate correctly. During cell division,...

2013-11-25 04:20:04

Tokyo, Nov 25, 2013 - (ACN Newswire) - Researchers at Waseda University in Japan have for the first time directly observed the "molecular motor", called Xkid, that plays a critical role in facilitating the proper alignment of chromosomes during cell division. Their findings are expected to contribute greatly to elucidating the molecular mechanisms of chromosome segregation, a key aspect of the development of certain medical disorders including cancer and birth defects.A human being begins as...

2013-09-12 11:36:20

In a study to be published in the journal Nature, two Dartmouth researchers have found that the protein cyclin A plays an important but previously unknown role in the cell division process, acting as a master controller to ensure the faithful segregation of chromosomes during cell division. Cell division is the process in which cells reproduce by splitting into two identical copies. This process happens trillions of times in an average person's lifetime. To generate two identical copies,...

2013-08-08 15:15:20

Researchers at Warwick Medical School have identified the key role played by a team of proteins in the process of mitosis. Working out how to control them may give scientists a way to destroy cancerous cells. The study, published in The Journal of Cell Biology, highlights the role of a newly identified team of proteins, TACC3-ch-TOG-clathrin, in forming inter-microtubule bridges that stabilize the kinetochore fibers (K-fibers) used in mitosis. When a cell divides, it produces a mitotic...

2012-12-26 12:46:07

New York University biologists have identified how a vital protein is loaded by others into the centromere, the part of the chromosome that plays a significant role in cell division. Their findings shed new light on genome replication and may offer insights into the factors behind the production of abnormal numbers of chromosomes. Their findings appear in the latest issue of the journal the Proceedings of the National Academy of Sciences. The researchers focused on the organization and...

2012-12-03 16:04:03

Researchers at the University of Geneva, Switzerland, demonstrate that the receptors that bind the toxin of this bacterium control how cell division is oriented Anthrax uses a receptor on the surface of cells to inject its lethal toxins. However, the physiological function of this receptor, named Anthrax Toxin Receptor 2a (Antxr2a), remained unknown until now. A team led by Marcos Gonzalez-Gaitan, a professor at the University of Geneva (UNIGE), Switzerland, in collaboration with Gisou van...

2012-11-09 11:08:49

Biologists have identified a new molecular player in asymmetric cell division, a protein named She1 whose role wasn't known before - This is important for self-renewal of stem cells and ensures that daughter cells have different fates and functions Recently biologists at the University of Massachusetts Amherst led by Wei-lih Lee have identified a new molecular player in asymmetric cell division, a regulatory protein named She1 whose role in chromosome- and spindle positioning wasn't known...

2012-08-21 10:31:50

The Nek9 protein is required for chromosomes to separate into two identical groups. Nek9 exerts its action between two molecules of interest for the pharmaceutical industry as anti-tumoral agents, and for which inhibitors are already in advanced stages of clinical trials. Nek9 could be added to the list of candidates. A study by the Institute for Research in Biomedicine (IRB Barcelona) and the Center for Genomic Regulation (acronym in Catalan CRG) highlights the protein Nek9 as a...

2011-11-04 22:57:59

The histone protein CenH3 is both necessary and sufficient to trigger the formation of centromeres and pass them on from 1 generation to the next Centromeres are specialised regions of the genome, which can be identified under the microscope as the primary constriction in X-shaped chromosomes. The cell skeleton, which distributes the chromosomes to the two daughter cells during cell division, attaches to the centromeres. In most organisms the position of the centromere is not determined by...

422d2981c94c807c0c4f3d4cb7d9e3af
2011-08-18 13:48:11

When an egg cell is being formed, the cellular machinery which separates chromosomes is extremely imprecise at fishing them out of the cell's interior, scientists at the European Molecular Biology Laboratory (EMBL) in Heidelberg, Germany, have discovered. The unexpected degree of trial-and-error involved in this process could explain why errors in the number of chromosomes in the egg cell are the leading cause of miscarriages and severe congenital diseases such as trisomies like Down's...


Word of the Day
baudekin
  • A rich embroidered or brocaded silk fabric woven originally with a warp of gold thread.
'Baudekin' seems to be an alternative form of 'baldachin,' from the Italian 'Baldacco,' Baghdad, the city where the material was made.
Related