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Latest KiSS1-derived peptide receptor Stories

2013-07-17 10:55:52

During the last decade, our understanding of this hypothalamus-pituitary-gonadal axis has quickly expanded. Two novel hypothalamic Arg-Phe-amide- related peptides, kisspeptin and gonadotropin-inhibitory hormone, may be important regulators of the reproductive axis. Kisspeptins are currently recognized as the most potent activators of the hypothalamus-pituitary-gonadal axis. Kisspeptin and its receptor, G protein-coupled receptor 54 (GPR54), are expressed on gonadotropin-releasing hormone...

2013-04-17 11:40:49

Spread of breast cancer linked to kisspeptins which normally inhibit metastasis KISS 1 is a metastasis-suppressor gene which helps to prevent the spread of cancers, including melanoma, pancreatic and ovarian cancers to name a few. But new research from Western University's Schulich School of Medicine & Dentistry shows that kisspeptins —peptide products of KISS1, actually make some breast cancers worse, with a higher tumor grade and metastatic potential. The research is published...

2012-06-27 00:56:05

Prenatal exposure to the environmental contaminants polychlorinated biphenyls, or PCBs, causes long-term changes to the developing brain that have adverse effects on reproductive function later in life, a new study finds. Results will be presented Saturday at The Endocrine Society's 94th Annual Meeting in Houston. The study used rats, whose genes and molecules in the hypothalamus–the region of the brain important for reproductive function–are virtually identical to those in...

2008-10-20 03:00:18

The international jury brought together by La Fondation Ipsen on June 2, 2006 in Toronto (Canada), under the presidency of Professor Iain Robinson (National Institute for Medical Research, London, UK) awarded the 6th Endocrine Communication and Regulation Prize to William F. Crowley (Harvard Medical School, Massachusetts General Hospital, Boston, USA) for his pioneering research on GnRH, a peptide hormone secreted by the hypothalamus which plays a role in the sexual development of humans. He...

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2008-09-03 13:35:00

Researchers say a small protein molecule in the brain plays a crucial ovulation-triggering role, a finding that could hold the key to new therapies for infertility. The protein, called kisspeptin, is known to play a vital role in kick-starting puberty. Now, the first evidence that kisspeptin signaling in the brain is also essential for ovulation to occur in adults has been published by a group from the University of Otago led by Professor Allan Herbison, in collaboration with Cambridge...


Word of the Day
negawatt
  • A unit of saved energy.
Coined by Amory Lovins, chairman of the Rocky Mountain Institute as a contraction of negative watt on the model of similar compounds like megawatt.