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Latest Klotho Stories

brain boosting genetic variant
2014-05-12 04:50:31

[ Watch the Video: Longevity Gene May Boost Brain Power ] redOrbit Staff & Wire Reports - Your Universe Online People possessing a variant of the longevity gene KLOTHO have demonstrated enhanced brain skills, regardless of factors such as age, sex or risk of Alzheimer’s disease, according to research published in the journal Cell Reports. The National Institutes of Health-funded study found that people with the variant had improved thinking, learning and memory. It also...

2013-10-09 12:08:08

A team of researchers at Georgetown University Medical Center (GUMC) has found that loss of an anti-aging gene induces retinal degeneration in mice and might contribute to age-related macular degeneration, the major cause of blindness in the elderly. In the Oct. 9 issue of the Journal of Neuroscience, the scientists demonstrated a key role for the aging-suppressor gene Klotho in maintaining the health of the mouse and human retina. They say that in their animal studies, loss of Klotho...

2012-09-20 16:50:12

Scientists have identified a key molecular player in a chain of events in the body that can lead to fatty liver disease, Type II diabetes and other metabolic abnormalities associated with obesity. By blocking this molecule, the researchers were able to reverse some of the pathology it caused in obese mice. Their findings appear in the Proceedings of the National Academy of Sciences. MiR-34a (pronounced MEER-34a), a micro-RNA, occurs at higher than normal levels in the livers of obese...

2011-04-14 12:32:07

A natural hormone known to inhibit aging can also protect kidneys against renal fibrosis, UT Southwestern Medical Center researchers have demonstrated. Scientists led by Dr. Makoto Kuro-o, associate professor of pathology, showed in mice that the anti-aging hormone Klotho suppressed both renal fibrosis "“ a common complication of chronic kidney disease "“ and the spread of cancer. The findings are available online in the Journal of Biological Chemistry. More than 26 million people...

2011-02-18 17:19:43

Low levels of the anti-aging hormone Klotho may serve as an early warning sign of the presence of kidney disease and its deadly cardiovascular complications, according to findings by UT Southwestern Medical Center researchers. Using mice, investigators found that soft-tissue calcification, a common and serious side effect of chronic kidney disease (CKD), improves when Klotho hormone levels are restored. The study is available online in the Journal of the American Society of Nephrology. The...

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2010-04-26 15:17:23

New research in the FASEB Journal shows that high levels of phosphate in sodas and processed foods accelerate the aging process in mice and contribute to age-associated complications such as chronic kidney disease Here's another reason to kick the soda habit. New research published online in the FASEB Journal (http://www.fasebj.org) shows that high levels of phosphates may add more "pop" to sodas and processed foods than once thought. That's because researchers found that the high levels of...

2009-08-20 12:16:29

U.S. scientists say they have determined the first link between a newly discovered anti-aging gene and high blood pressure. University of Oklahoma Health Sciences Center researchers say their achievement offers new clues on how we age and how we might live longer. The researchers, led by Dr. Zhongjie Sun, an associate professor of physiology, tested the effect of an anti-aging gene called klotho on reducing hypertension. They found by increasing the expression of the gene in laboratory...

2009-08-19 16:06:21

 Researchers at the University of Oklahoma Health Sciences Center have shown the first link between a newly discovered anti-aging gene and high blood pressure. The results, which appear this month in the journal Hypertension, offer new clues on how we age and how we might live longer.Persistent hypertension, or high blood pressure, is a risk factor for stroke, heart attack, heart failure, arterial aneurysm and is the leading cause of chronic kidney failure. Even a modest elevation of...

2005-11-03 15:23:23

Bethesda, MD - Scientists recently discovered an anti-aging hormone called Klotho. Now, a new study shows that this protein acts by increasing the cell's ability to detoxify harmful reactive oxygen species. The research appears as the "Paper of the Week" in the November 11 issue of the Journal of Biological Chemistry, an American Society for Biochemistry and Molecular Biology journal. The klotho gene, named after the Greek goddess who spins life's thread, is associated with preventing aging...

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2005-08-29 11:05:00

WASHINGTON -- Starving -- officially known as caloric restriction -- may make worms and mice live up to 50 percent longer but it will not help humans live super-long lives, two biologists argued on Sunday. They said their mathematical model showed that a lifetime of low-calorie dieting would only extend human life span by about 7 percent, unlike smaller animals, whose life spans are affected more by the effects of starvation. This is because restricting calories only indirectly affects life...


Word of the Day
bodacious
  • Remarkable; prodigious.
  • Audacious; gutsy.
  • Completely; extremely.
  • Audaciously; boldly.
  • Impressively great in size; enormous; extraordinary.
This word is probably from the dialectal 'boldacious,' a blend of 'bold' and 'audacious.'
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