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Latest Knockout mouse Stories

2014-04-18 12:22:30

RnRMarketResearch.com adds "Mice Model Market - by Type [Inbred, Knockout, Conditioned], Technology [Microinjection, Embryonic Stem Cell], Disease [Oncology, Immunology, CNS], Service [Breeding, Cryopreservation, Quarantine] & Care Products [Cages, Bedding, Feed] - Forecasts to 2018" to its store. DALLAS, April 18, 2014 /PRNewswire-iReach/ -- Over the years, the mice model market, which includes models and services, has witnessed many innovations that have led to an increase in the...

2014-01-08 23:22:27

RnRMarketResearch.com adds “Mice Model Market – by Type [Inbred, Knockout, Conditioned], Technology [Microinjection, Embryonic Stem Cell], Disease [Oncology, Immunology, CNS], Service [Breeding, Cryopreservation, Quarantine] & Care Products [Cages, Bedding, Feed] – Forecasts to 2018” to its store. Dallas, Texas (PRWEB) January 08, 2014 Over the years, the mice model market, which includes models and services, has witnessed many innovations that have led to an increase in the...

2012-04-27 00:01:19

The ability to navigate using spatial cues was impaired in mice whose brains were minus a channel that delivers potassium – a finding that may have implications for humans with damage to the hippocampus, a brain structure critical to memory and learning, according to a Baylor University researcher. Mice missing the channel also showed diminished learning ability in an experiment dealing with fear conditioning, said Joaquin Lugo, Ph.D., the lead author in the study and an assistant...

2011-09-27 11:18:54

For decades, laboratory mice have been widely used in research aimed at understanding which genes are involved in various illnesses. But actual variations in past gene sequences of mice were unknown. While researchers were able to determine that a variant affecting disease was in a certain region, they couldn't pinpoint the exact set of variants in that region. Now, in new research recently published in the journal Nature, an international team of investigators that included UCLA...

2011-07-28 12:49:08

In humans, inherited mutations in a gene called HPRT1 lead to very specific self-destructive behavior. Boys with Lesch-Nyhan disease experience uncontrollable urges to bite their fingers, slam their arms into doorways and otherwise harm themselves. Puzzlingly, mice with mutations in the same gene don't behave differently than normal mice. Researchers at Emory University School of Medicine have identified a gene related to HPRT1, present in humans but not in mice that helps explain this...

2011-05-16 15:51:21

Today's anticancer drugs often work wonders against malignancies, but sometimes tumors become resistant to the effects of such drugs, and treatment fails. Medical researchers would like to find ways of counteracting such resistance, but first they must understand why and how it happens. New findings by Fox Chase Cancer Center researchers identify one protein, Abcc10 (also known as Mrp7), as being intimately involved in resistance to certain drugs used to treat breast, ovarian, lung, and other...

2011-03-11 08:44:19

(Ivanhoe Newswire) -- Ten years ago, research scientist began trying to understand how a specific feature of a cell called an L-type calcium channel might be related to genetic deafness syndrome. This specific feature created a knockout mouse missing both copies of the CACNA1D gene; a gene which makes protein, and allows calcium to flow into other cells. The CACNA1D gene is also important in relaying important instructions from one cell to another. Although the knockout mouse was created...

2010-12-20 08:16:06

(Ivanhoe Newswire) -- It turns out our ancient ancestors may be to blame for the obesity epidemic.  According to a research team at the Salk Institute of Biological Studies, evolutionary adaptations may have genetically shaped how our body stores and burns fat. Led by Marc Montminy, M.D., Ph.D, and professor at the Clayton Foundation Laboratories for Peptide Biology, the team studied a particular gene called CRT3, which is responsible for decreasing energy expenditure in fat cells....

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2010-12-16 09:04:37

In addition to fast food, desk jobs, and inertia, there is one more thing to blame for unwanted pounds-our genome, which has apparently not caught up with the fact that we no longer live in the Stone Age. That is one conclusion drawn by researchers at the Salk Institute for Biological Studies, who recently showed that mice lacking a gene regulating energy balance are protected from weight gain, even on a high fat diet. These findings have implications for the worldwide obesity epidemic and...


Latest Knockout mouse Reference Libraries

Knockout Mouse
2013-10-02 11:52:01

A Knockout Mouse is a genetically engineered mouse in which researchers have inactivated, or “knocked out,” an existing gene by replacing it or disrupting it with an artificial piece of DNA. The loss of gene activity frequently causes changes in a mouse’s phenotype, which includes appearance, behavior, or other apparent and biochemical characteristics. Knockout mice are significant animal models for studying the role of genes which have been sequenced but whose functions haven’t...

42_ab721bccab54c7f7ca8dd61e19cacdd4
2007-08-10 16:14:02

The Common House Mouse (Mus musculus), is the most numerous species of the genus Mus. It is the most common and populous mammalian species on earth, besides humans. House mice almost always live in close proximity to humans. Laboratory mice belong to strains of house mice and are some of the most important model organisms in biology and medicine. They are by far the most commonly used laboratory mammal. House mice are light brown to black, with short hair and a light belly. The ears and...

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Word of the Day
vermicular
  • Like a worm in form or movement; vermiform; tortuous or sinuous; also, writhing or wriggling.
  • Like the track or trace of a worm; appearing as if worm-eaten; vermiculate.
  • Marked with fine, close-set, wavy or tortuous lines of color; vermiculated.
  • A form of rusticated masonry which is so wrought as to appear thickly indented with worm-tracks.
This word ultimately comes from the Latin 'vermis,' worm.
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