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Latest Knockout mouse Stories

2010-12-13 06:03:43

(Ivanhoe Newswire) -- Deleting the receptor, not the protein ghrelin itself, turns up the body's fat-burning thermostat, giving aging mice an exothermic boost toward a svelte physique, researchers recently reported. The protein's receptor, growth hormone secretagogue receptor (GHS-R), might make a better target than ghrelin for treating obesity, according to Sun said that experimentally deleting the receptor from the body cells of laboratory mice prevented obesity by diminishing white adipose...

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2010-12-09 10:14:37

Researchers at the University of Hawai'i at Mānoa have developed innovative techniques that could have profound effects on congenital cervical vertebrae malformation research. In the cover-featured research article of the November issue of Molecular Reproduction and Development, researchers looked into congenital cervical vertebrae malformation in humans that can cause neural problems and increase susceptibility to stillbirth in women. Research advancement on...

2010-10-15 16:32:31

Researchers at the University of Minnesota Medical School have gained insight into how different types of age-related hearing loss may occur in humans. The discovery could eventually help physicians develop drugs to combat progressive hearing loss. Their paper is published on October 14 in the open-access journal PLoS Genetics. James Ervasti, Ph.D., and colleague Ben Perrin, Ph.D., studied how two very closely related genes contribute to hearing function in mice. Mutations in the same genes...

2010-09-09 01:06:59

Removal of Key Protein Leads to Initiation of Disease Elimination of a molecular gatekeeper leads to the development of arthritis in mice, scientists report in a study published in The Journal of Experimental Medicine. The newly discovered gatekeeper is a protein that determines the fate "“ survival or death "“ of damaging cells that mistakenly attack the body's own tissues and lead to autoimmune disorders such as arthritis.  Better understanding how arthritis develops will...

2010-07-08 13:50:08

The mammalian fucose mutarotase enzyme is known to be involved in incorporating the sugar fucose into protein. Female mice that lack the fucose mutarotase (FucM) gene refuse to let males mount them, and will attempt copulation with other female mice. Researchers writing in BioMed Central's open access journal BMC Genetics created the FucM mouse mutants in order to investigate the role of this enzyme in vivo. Chankyu Park worked with a team of researchers from the Korea Advanced Institute of...

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2010-04-25 13:23:04

First mice, then fruit flies, and now knockout nematodes Knocking genes out of action allows researchers to learn what genes do by seeing what goes wrong without them. University of Utah biologists pioneered the field. Mario Capecchi won a Nobel Prize for developing knockout mice. Kent Golic found a way to cripple fruit fly genes. Now, biologist Erik Jorgensen and colleagues have devised a procedure for knocking out genes in nematode worms. "We developed a method that allows us to walk...

2010-03-15 16:04:56

A quest that began over a decade ago with a chance observation has reached a milestone: the identification of a gene that may regulate regeneration in mammals. The absence of this single gene, called p21, confers a healing potential in mice long thought to have been lost through evolution and reserved for creatures like flatworms, sponges, and some species of salamander. In a report published today in the Proceedings of the National Academy of Sciences, researchers from The Wistar Institute...

2010-03-08 00:00:00

ST. LOUIS, March 8 /PRNewswire-FirstCall/ -- Sigma® Life Science, an innovative brand of Sigma-Aldrich® (Nasdaq: SIAL), today extended its portfolio of knockout rat models with the announcement of a new suite of models designed to facilitate more predictive absorption, distribution, metabolism, excretion and toxicity (ADME/Tox) studies. This extension of the Company's product offering, the first ever models created especially for ADME/Tox applications,...

2009-12-22 14:00:28

Johns Hopkins Scientists Find a Source of Nonallergic Itch Scratching below the surface of a troublesome sensation that's equal parts tingle-tickle-prickle, sensory scientists from Johns Hopkins have discovered in mice a molecular basis for nonallergic itch. Using the itch-inducing compound chloroquine, an antimalarial drug, the team identified that a family of proteins called Mrgprs, found only in a rare subset of nerve cells, functions as itch receptors. A report on the research appears...

2009-12-03 21:25:41

Howard Hughes Medical Institute (HHMI) researchers have identified a new factor that is necessary for the development of many forms of medulloblastoma, the most common type of malignant childhood brain cancer. HHMI investigator Huda Y. Zoghbi and colleagues at Baylor College of Medicine prevented medulloblastoma from developing in mice by shutting down production of the protein Atoh1 in susceptible brain cells. The team's findings, reported in the December 4, 2009, issue of Science, suggest...


Latest Knockout mouse Reference Libraries

Knockout Mouse
2013-10-02 11:52:01

A Knockout Mouse is a genetically engineered mouse in which researchers have inactivated, or “knocked out,” an existing gene by replacing it or disrupting it with an artificial piece of DNA. The loss of gene activity frequently causes changes in a mouse’s phenotype, which includes appearance, behavior, or other apparent and biochemical characteristics. Knockout mice are significant animal models for studying the role of genes which have been sequenced but whose functions haven’t...

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2007-08-10 16:14:02

The Common House Mouse (Mus musculus), is the most numerous species of the genus Mus. It is the most common and populous mammalian species on earth, besides humans. House mice almost always live in close proximity to humans. Laboratory mice belong to strains of house mice and are some of the most important model organisms in biology and medicine. They are by far the most commonly used laboratory mammal. House mice are light brown to black, with short hair and a light belly. The ears and...

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Word of the Day
bibliopole
  • A bookseller; now, especially, a dealer in rare and curious books.
This word comes from a Greek phrase meaning 'book seller.'
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