Latest Knockout mouse Stories
Howard Hughes Medical Institute (HHMI) researchers have identified a new factor that is necessary for the development of many forms of medulloblastoma, the most common type of malignant childhood brain cancer.
Removing the PKCI/HINT1 gene from mice has an anti-depressant-like and anxiolytic-like effect.
ST. LOUIS, Oct. 19 /PRNewswire-FirstCall/ -- Sigma-AldrichÂ® (Nasdaq: SIAL) today announced the launch of SAGEspeed(TM), a program to develop human disease models in rodents using its proprietary novel CompoZr(TM) Zinc Finger Nuclease (ZFN) gene editing technology (http://www.compozrzfn.com).
Scientists have discovered a new method that has proven to extend the lifespan of mice by up to a fifth, which could lead to the development of new anti-aging drug treatments.
University of Michigan researchers have identified a gene that acts as a master switch to control obesity in mice. When the switch is turned off, even high-fat-diet mice remain thin.
Investigators at Burnham Institute for Medical Research (Burnham) and the University of Connecticut Health Center (U.C.H.C.) have gained new understanding of the role hyaluronic acid (HA) plays in skeletal growth, chondrocyte maturation and joint formation in developing limbs.
The secret to longevity may lie in an enzyme with the ability to promote a robust immune system into old age by maintaining the function of the thymus throughout life, according to researchers studying an "anti-aging" mouse model that lives longer than a typical mouse.
In a new study that could transform embryonic stem cell (ES cell) research, scientists at UT Southwestern Medical Center have discovered why mouse ES cells can be easily grown in a laboratory while other mammalian ES cells are difficult, if not impossible, to maintain.
Deleting two genes in mice responsible for repairing DNA strands damaged by oxidation leads to several types of tumors, providing additional evidence that such stress contributes to the development of cancer.
Scientists of the German Mouse Clinic at Helmholtz Zentrum MÃ¼nchen have generated and analyzed a mouse model in which parts of the human Foxp2 gene were introduced. Foxp2 is known to be a key gene for language.
A Knockout Mouse is a genetically engineered mouse in which researchers have inactivated, or “knocked out,” an existing gene by replacing it or disrupting it with an artificial piece of DNA. The loss of gene activity frequently causes changes in a mouse’s phenotype, which includes appearance, behavior, or other apparent and biochemical characteristics. Knockout mice are significant animal models for studying the role of genes which have been sequenced but whose functions haven’t...
The Common House Mouse (Mus musculus), is the most numerous species of the genus Mus. It is the most common and populous mammalian species on earth, besides humans. House mice almost always live in close proximity to humans. Laboratory mice belong to strains of house mice and are some of the most important model organisms in biology and medicine. They are by far the most commonly used laboratory mammal. House mice are light brown to black, with short hair and a light belly. The ears and...