Latest Knockout mouse Stories
Knockout of myostatin, a growth factor that limits muscle growth, can decrease body fat and promote resistance against developing atherosclerosis, or "hardening" of the arteries, according to a new study conducted in mice. The results will be presented Thursday at The Endocrine Society's 91st Annual Meeting in Washington, D.C.
An international team of researchers have finished sequencing the mouse genome after a 10-year effort.
Parallel studies in mice and humans by Spanish and British scientists have found a new kind of genes -- micro RNAs -- are linked to progressive hearing loss. The researchers said their findings provide important new genetic understanding of a condition that's common in humans yet remains poorly understood. The Spanish scientists from the Hospital Ramon Cajal in Madrid followed families who showed hearing loss.
Scientists at the University of North Carolina at Chapel Hill School of Medicine have discovered a gene that when mutated causes obesity by dampening the body's ability to burn energy while leaving appetite unaffected.
Researchers have for the first time attempted to count the number of genes that contribute to obesity and body weight. The findings suggest that over 6,000 genes -- about 25 percent of the genome -- contribute to help determine an individual's body weight.
Howard Hughes Medical Institute researchers have harnessed a mobile gene from the cabbage looper moth and modified it for routine use to determine the function of genes in mice and other vertebrates. If the new tool works as they expect, it will speed understanding of genes involved in human biology and disease and accelerate the search for effective new therapies.
They're being bred now by the millions, the mutants, created to carry the ghastliest of diseases for the benefit of the human race. Since researchers published the mouse's entire genetic makeup in map form three years ago, increasingly exotic rodents are being created with relative ease.
A Knockout Mouse is a genetically engineered mouse in which researchers have inactivated, or “knocked out,” an existing gene by replacing it or disrupting it with an artificial piece of DNA. The loss of gene activity frequently causes changes in a mouse’s phenotype, which includes appearance, behavior, or other apparent and biochemical characteristics. Knockout mice are significant animal models for studying the role of genes which have been sequenced but whose functions haven’t...
The Common House Mouse (Mus musculus), is the most numerous species of the genus Mus. It is the most common and populous mammalian species on earth, besides humans. House mice almost always live in close proximity to humans. Laboratory mice belong to strains of house mice and are some of the most important model organisms in biology and medicine. They are by far the most commonly used laboratory mammal. House mice are light brown to black, with short hair and a light belly. The ears and...