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Latest Knockout mouse Stories

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2009-05-27 10:50:00

An international team of researchers have finished sequencing the mouse genome after a 10-year effort. Their new paper explores exactly what distinguishes our genome from that of the lab mouse, BBC News reported. Researchers in laboratories around the world have made the tiny mouse their experimental workhorse and scientists are now confident this high-quality genome sequence will aid in the fight against human disease. Experts say possessing a greater understanding of the genetic code of...

2009-04-14 12:22:07

Parallel studies in mice and humans by Spanish and British scientists have found a new kind of genes -- micro RNAs -- are linked to progressive hearing loss. The researchers said their findings provide important new genetic understanding of a condition that's common in humans yet remains poorly understood. The Spanish scientists from the Hospital Ramon Cajal in Madrid followed families who showed hearing loss. The second team, led by British researchers from the Wellcome Trust Sanger...

2009-02-05 13:16:20

U.S. medical researchers say they have discovered a possible new obesity drug target that doesn't involve altering brain function. The researchers, led by University of North Carolina School of Medicine Professor Yi Zhang, said they discovered the gene Jhdm2a, when mutated, causes obesity by dampening the body's ability to burn energy while leaving appetite unaffected. The finding, said Zhang, might lead to new pharmacologic approaches to treating obesity in humans. The study focused on a...

2009-02-05 10:16:48

Scientists at the University of North Carolina at Chapel Hill School of Medicine have discovered a gene that when mutated causes obesity by dampening the body's ability to burn energy while leaving appetite unaffected.The new research could potentially lead to new pharmacologic approaches to treating obesity in humans that do not target the brain, according to study senior author Yi Zhang, Ph.D., Howard Hughes Medical Institute investigator and professor of biochemistry and biophysics in the...

65ef677cf514439524e86ee0a567d99e1
2008-01-14 15:55:00

Obesity quick fix unlikely; problem even more complex than previously thoughtPHILADELPHIA "“ Reporting in the online journal BMC Genetics, researchers from the Monell Center have for the first time attempted to count the number of genes that contribute to obesity and body weight. The findings suggest that over 6,000 genes "“ about 25 percent of the genome "“ help determine an individual's body weight. "Reports describing the discovery of a new "Ëœobesity gene' have...

2005-08-11 21:35:00

Howard Hughes Medical Institute researchers have harnessed a mobile gene from the cabbage looper moth and modified it for routine use to determine the function of genes in mice and other vertebrates. If the new tool works as they expect, it will speed understanding of genes involved in human biology and disease and accelerate the search for effective new therapies. The researchers report their study in the August 12, 2005, issue of the journal Cell. Certain genes or genetic elements, called...

c74833eabca59e1f61a2b1aff280ff691
2005-08-06 00:10:00

SAN FRANCISCO -- They're being bred now by the millions, the mutants, created to carry the ghastliest of diseases for the benefit of the human race. Since researchers published the mouse's entire genetic makeup in map form three years ago, increasingly exotic rodents are being created with relative ease. There's the Schwarzenegger mouse - injected with muscle-building genes. The marathon mouse, which never seems to tire. Researchers recently engineered some mice to be extremely addicted to...


Latest Knockout mouse Reference Libraries

Knockout Mouse
2013-10-02 11:52:01

A Knockout Mouse is a genetically engineered mouse in which researchers have inactivated, or “knocked out,” an existing gene by replacing it or disrupting it with an artificial piece of DNA. The loss of gene activity frequently causes changes in a mouse’s phenotype, which includes appearance, behavior, or other apparent and biochemical characteristics. Knockout mice are significant animal models for studying the role of genes which have been sequenced but whose functions haven’t...

42_ab721bccab54c7f7ca8dd61e19cacdd4
2007-08-10 16:14:02

The Common House Mouse (Mus musculus), is the most numerous species of the genus Mus. It is the most common and populous mammalian species on earth, besides humans. House mice almost always live in close proximity to humans. Laboratory mice belong to strains of house mice and are some of the most important model organisms in biology and medicine. They are by far the most commonly used laboratory mammal. House mice are light brown to black, with short hair and a light belly. The ears and...

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