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Latest KRAS Stories

2011-11-09 10:12:25

Method can be implemented into routine clinical practice, bringing effective personalized medicine a step closer Researchers in the United States have shown, for the first time, that it is possible to screen cancer patients for a broad range of cancer-causing genetic mutations as part of normal clinical practice. By identifying patients' individual genotypes within a relatively short time frame, doctors are able to target tumors with the most appropriate therapy. The study, which is...

2011-10-10 19:35:28

Some cancers can be effectively treated with drugs inhibiting proteins known as receptor tyrosine kinases, but not those cancers caused by mutations in the KRAS gene. A team of researchers led by Jeffrey Engelman, at Massachusetts General Hospital Cancer Center, Boston, has now identified a potential way to effectively use receptor tyrosine kinases inhibitors to treat individuals with KRAS mutant colorectal cancers – combine them with inhibitors of the MEK/ERK signaling pathway. In...

2011-08-16 01:00:00

GERMANTOWN, Maryland and HILDEN, Germany, August 16, 2011 /PRNewswire/ -- - Diagnostic-therapeutic combination aims to improve standard of care for patients with non-small cell lung cancer (NSCLC) - Molecular test for KRAS gene mutations holds potential to help determine whether there is a subset of patients who are more likely to benefit from Pfizer's investigational anticancer compound - Collaboration in lung cancer...

2011-08-05 02:00:00

GERMANTOWN, Maryland and HILDEN, Germany, August 5, 2011 /PRNewswire/ -- ? - Food and Drug Administration will review therascreen(R) KRAS RGQ PCR Kit for use with Erbitux(R) (cetuximab), a metastatic colorectal cancer therapy - PMA follows a recent submission for use with another EGFR inhibitor drug, also in patients with metastatic colorectal cancer - QIAGEN achieves milestones in Personalized Healthcare with...

2011-07-27 07:35:00

QUEBEC CITY, July 27, 2011 /PRNewswire/ - Aeterna Zentaris Inc. (NASDAQ: AEZS) (TSX: AEZ) (the "Company") today announced the completion of patient recruitment for the ongoing Phase 3 trial with perifosine in refractory advanced colorectal cancer. The trial, involving over 430 patients, is being conducted pursuant to a Special Protocol Assessment (SPA) with the Food and Drug Administration (FDA) and with Fast Track Designation. It is sponsored by Keryx Biopharmaceuticals, Inc.,...

2011-07-27 07:30:00

NEW YORK, July 27, 2011 /PRNewswire/ -- Keryx Biopharmaceuticals, Inc. (Nasdaq: KERX) today announced completion of patient enrollment in its Phase 3 registration trial of KRX-0401 (perifosine) for the treatment of refractory, advanced colorectal cancer. This Phase 3 trial, with over 430 randomized patients, is being conducted pursuant to a Special Protocol Assessment (SPA) with the Food and Drug Administration (FDA) and with Fast-Track Designation. Perifosine is a novel, potentially...

2011-07-20 17:27:41

Johns Hopkins scientists have developed a gene-based test to distinguish harmless from precancerous pancreatic cysts. The test may eventually help some patients avoid needless surgery to remove the harmless variety. A report on the development is published in the July 20 issue of Science Translational Medicine. The investigators estimate that fluid-filled cysts are identified in more than a million patients each year, most of whom have undergone CT or MRI scans to evaluate non-specific...

2011-07-06 06:00:00

CALGARY, July 6, 2011 /PRNewswire/ - Oncolytics Biotech Inc. (TSX:ONC, NASDAQ:ONCY) ("Oncolytics") today announced that a presentation covering interim preliminary results from a Phase 2 clinical trial using intravenous administration of REOLYSIN(® )in combination with paclitaxel and carboplatin in patients with non-small cell lung cancer (NSCLC) with Kras or EGFR-activated tumours was made today at the International Association for the Study of Lung Cancer World...


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