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Last updated on April 23, 2014 at 13:35 EDT

Latest Lafora disease Stories

2012-05-02 13:29:29

Work by IRB Barcelona researchers will further the study of neurodegenerative diseases such as Lafora progressive myoclonic epilepsy Collaborative research by groups headed by scientists Joan J. Guinovart and Marco Milán at the Institute for Research in Biomedicine (IRB Barcelona) has revealed conclusive evidence about the harmful effects of the accumulation of glucose chains (glycogen) in fly and mouse neurons. These two animal models will allow scientists to address the...

2011-08-29 14:07:13

Researchers at IRB Barcelona have demonstrated a link between abnormal sugar accumulation and the neuronal degeneration characteristic of Lafora disease Short-term energy storage in animal cells is usually achieved through the accumulation of glucose, in the form of long and branched chains, known as glycogen. But when this accumulation happens in neurons it is fatal, causing them to degenerate. This neuronal deterioration and death associated with glycogen accumulation is the hallmark of...

2011-03-02 13:08:25

Indiana University scientists have solved a perplexing mystery regarding one of the body's main energy storage molecules, in the process shedding light on a possible route to treatment of a rare but deadly disease in teenagers. The disease occurs when a genetic mutation causes excessive amounts of phosphate to build up in glycogen. Glycogen is a chain-like molecule the body uses to temporarily store glucose when it's not needed to provide energy for cellular activities. The excess phosphate...

2011-03-02 01:59:12

A new study offers critical insight into the biochemistry of a rare and fatal form of epilepsy known as Lafora disease, a genetic condition that typically strikes children in their teens A new study offers critical insight into the biochemistry of a rare and fatal form of epilepsy known as Lafora disease, a genetic condition that typically strikes children in their teens. The disease is characterized by the buildup of a "wrecked" form of glycogen, a stored form of glucose, in the brain and...