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Latest Laminin Stories

2014-02-13 16:28:10

Experimental Protein Replacement Therapy for Congenital Muscular Dystrophy Type 1A (MDC1A) MILFORD, Mass. and RENO, Nev., Feb. 13, 2014 /PRNewswire/ -- Prothelia Incorporated (Prothelia) and University of Nevada, Reno announce that they have entered into strategic agreements with Alexion for the development of Laminin-111, a patented experimental protein replacement therapy for merosin-deficient congenital muscular dystrophy (MDC1A), a life-threatening, ultra-rare disease caused by a genetic...

2012-10-24 23:40:46

Boosting the activity of a vitamin-sensitive cell adhesion pathway has the potential to counteract the muscle degeneration and reduced mobility caused by muscular dystrophies, according to a research team led by scientists at the University of Maine. The discovery, published 23 October in the open access journal PLOS Biology, is particularly important for congenital muscular dystrophies, which are progressive, debilitating and often lethal diseases that currently remain without cure. The...

2012-01-09 19:10:35

Study reveals function of glycosylating enzyme involved in muscular dystrophy, brain development and infection by arenaviruses such as Lassa fever; ability to assay enzyme activity could help screen potential muscular dystrophy therapies Researchers at the University of Iowa have worked out the exact function of an enzyme that is critical for normal muscle structure and is involved in several muscular dystrophies. The findings, which were published Jan. 6 in the journal Science, could be...

2011-07-08 14:21:03

For patients suffering from epidermolysis bullosa (EB), a hereditary skin disease, even a gentle touch is extremely painful. Now Dr. Li-Yang Chiang, Dr. Kate Poole and Professor Gary R. Lewin of the Max Delbrck Center for Molecular Medicine (MDC) in Berlin-Buch have discovered the causes underlying this disease. Due to a genetic defect, individuals with EB cannot form laminin-332, a structural molecule of the skin that in healthy individuals inhibits the transduction of tactile stimuli and...

2011-03-07 21:34:47

Laminin, long thought to be only a structural support protein in the microenvironment of breast and other epithelial tissue, is "famous" for its cross-like shape. However, laminin is far more than just a support player with a "pretty face." Two studies led by one of the world's foremost breast cancer scientists have shown how laminin plays a central role in the development of breast cancer, the second most leading cause of cancer death among women in the United States. In one study it was...

2010-06-21 15:45:00

GRAND RAPIDS, Mich., June 21 /PRNewswire/ -- Action Fabricators announced today it has expanded its medical division with the launch of Laminin Medical Products (www.LamininMedical.com), which will focus on the engineering, manufacturing and assembly/packaging of medical products under contract with the Medical Device industry. Laminin, with the help of a Michigan Economic Development Corporation (MEDC) grant through their Economic Development Job Training (EDJT) Program, showcased its...

2010-06-01 14:52:21

For the first time, human embryonic stem cells have been cultured under chemically controlled conditions without the use of animal substances, which is essential for future clinical uses. The method has been developed by researchers at Karolinska Institutet and is presented in the journal Nature Biotechnology. Embryonic stem cells can be turned into any other type of cell in the body and have potential uses in treatments where sick cells need to be replaced. One problem, however, is that it...

2010-01-01 10:37:46

With the discovery of a new type of chemical modification on an important muscle protein, a University of Iowa study improves understanding of certain muscular dystrophies and could potentially lead to new treatments for the conditions. The findings, which appear in the Jan. 1, 2010, issue of the journal Science, may also have implications for detecting metastasizing cancer cells. After they are initially made, most proteins are modified through the addition of sugar chains, fats or other...

2008-12-30 09:52:51

Current research suggests laminin, a protein that helps cells stick together, may lead to enhanced muscle repair in muscular dystrophy. The related report by Rooney et al, "Laminin-111 restores regenerative capacity in a mouse model for alpha 7 integrin congenital myopathy," appears in the January 2009 issue of The American Journal of Pathology. Muscular dystrophy is a group of inherited genetic diseases that cause progressive muscle weakness. In one type of muscular dystrophy, patients with...

2008-07-31 21:00:37

PALO ALTO, Calif. _ Watch out, Rogaine. Stanford University researchers have pinpointed a molecule that triggers hair follicle growth in mice, a treatment that one day could eventually mean some shaggy dos, or at least a few more strands, for humans who have experienced hair loss. The report, published Thursday in the Journal of Genes and Development, focuses on a molecule called laminin-511. The molecule acts like an operator, transferring messages, or proteins, between the outer and...


Word of the Day
glogg
  • Scandinavian punch made of claret and aquavit with spices and raisins and orange peel and sugar.
This word comes from the Swedish 'glogg,' which is an alteration of 'glodgat,' mulled (wine).
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