Latest Lapatinib Stories

A breast cancer chemotherapy drug shows benefits in fighting one type of breast cancer but not another type, U.S. researchers say. The study, published in the journal Clinical Cancer Research, found the oral chemotherapy drug lapatinib benefits women with HER2-positive breast cancer, while women with HER2-negative breast cancer, or those who express EGRF alone, derive no incremental benefit. In addition, a misclassification of metastatic breast cancer patients by as much as 10 percent...

A breast cancer chemotherapy drug shows benefits to one type of breast cancer but not for another type, U.S. researchers said. The study, published in the journal Clinical Cancer Research, found the oral chemotherapy drug lapatinib benefits women with HER2-positive breast cancer, while women with HER2-negative breast cancer or those who express EGRF alone derive no incremental benefit. In addition, a misclassification of metastatic breast cancer patients by as much as 10 percent prevents...

CAMBRIDGE, Mass., Oct. 22 /PRNewswire/ -- Millennium: The Takeda Oncology Company today announced new data from early non-clinical studies of Millennium/Takeda-discovered pipeline molecules highlighting novel therapeutic pathways in oncology. MLN4924 data build on the growing body of evidence supporting the importance of the Millennium-discovered Nedd8 Activating Enzyme (NAE) in tumor growth and survival. It is a first-in-class small molecule inhibitor of NAE. Both clinical and non-clinical...

WALTHAM, Mass., Oct. 21 /PRNewswire/ -- Decision Resources, one of the world's leading research and advisory firms for pharmaceutical and healthcare issues, finds that significant market penetration will drive Genentech/Roche/Chugai's Avastin to garner just over 20 percent of total sales in the breast cancer drug market in the United States, France, Germany, Italy, Spain, the United Kingdom and Japan in 2017. The new Pharmacor report entitled Breast Cancer finds that, through 2017, the...

By Liz Szabo Barbara Bradfield has lived to see dramatic changes in breast cancer. When she was diagnosed in 1989, Bradfield's tumor -- which produced an overabundance of a protein called HER2 -- was considered especially deadly. Today, women with tumors like hers have some of the best survival rates in breast cancer. Experts say the drug that has kept Bradfield healthy for so long, Herceptin, has changed the nature of breast cancer and helped doctors better understand what causes the...

By Martin Eatock A new drug called Lapatinib was recently hailed a "big step forward" for women suffering from advanced breast cancer. Consultant medical oncologist at the Belfast City Hospital, Dr Martin Eatock, argues that its true impact could be limited Lapatinib, used in combination with the chemotherapy drug capecitabine, was recently licensed for the treatment of Her-2 positive advanced breast cancer, an aggressive form of the disease which affects around a quarter of those women...

Wayne State University researchers say a breast cancer vaccine completely eliminated HER2-positive tumors in mice -- without any toxicity. The study, published in the journal Cancer Research, suggests the vaccine could treat women with HER2-positive, treatment-resistant cancer or help prevent cancer recurrence. The researchers also say it might potentially be used in cancer-free women to prevent initial development of these tumors. HER2 receptors promote normal cell growth, and are found in...

Cytokinetics, Incorporated (NASDAQ: CYTK) announced that data from its ongoing Phase I/II clinical trial of ispinesib were presented in a poster at the 2008 American Society of Clinical Oncology (ASCO) Breast Cancer Symposium held on September 5-7, 2008 in Washington, DC. A poster entitled, "A Phase I-II Trial of Ispinesib, a Kinesin Spindle Protein (KSP) Inhibitor, Dosed Every Two Weeks in Patients (pts) with Locally Advanced (LA) or Metastatic Breast Cancer (MBC) Previously Untreated with...

Many breast cancers are made worse by the hormone oestrogen and women take drugs known as aromatase inhibitors to reduce the oestrogen in their body and restrict the cancer's progress. But eventually the tumour becomes resistant to this treatment and starts to grow.Now American researchers said a drug called sorafenib may be able to reverse this process."At first, the tumour's growth is halted because the aromatase inhibitor is depriving the cancer of the oestrogen it needs to grow," says...

Cytokinetics, Incorporated (NASDAQ: CYTK) announced today that data from an ongoing Phase I/II clinical trial of ispinesib are scheduled to be presented as a poster presentation at the 2008 American Society of Clinical Oncology (ASCO) Breast Cancer Symposium, to be held September 5-7, 2008 at the Hilton Washington in Washington, DC. In June 2008, as part of a poster session at the ASCO Annual Meeting, Cytokinetics announced interim data from the Phase I portion of its ongoing Phase I/II...