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Latest Lewy body Stories

2011-08-15 12:16:27

Shape of key protein surprises researchers A new study finds that a protein key to Parkinson's disease has likely been mischaracterized. The protein, alpha-synuclein, appears to have a radically different structure in healthy cells than previously thought, challenging existing disease paradigms and suggesting a new therapeutic approach. "Our data show that alpha-synuclein was essentially mistakenly characterized as a natively unfolded protein that lacked structure," said Dennis Selkoe, the...

2011-07-12 12:31:00

A small protein called SUMO might prevent the protein aggregations that typify Parkinson's disease (PD), according to a new study in the July 11, 2011, issue of The Journal of Cell Biology (www.jcb.org). Insoluble protein clusters are the hallmarks of several neurodegenerative diseases. In PD, neurons harbor insoluble clumps of the protein alpha-synuclein. What triggers these protein pileups remains obscure. A possible clue for PD came when researchers overexpressed alpha-synuclein in human...

2011-07-12 07:37:42

(Ivanhoe Newswire) -- A small protein called SUMO might prevent the protein aggregations that typify Parkinson's disease (PD), according to this study. Insoluble protein clusters are the hallmarks of several neurodegenerative diseases. In PD, neurons harbor insoluble clumps of the protein alpha-synuclein. What triggers these protein pileups remains obscure. A possible clue for PD came when researchers overexpressed alpha-synuclein in human kidney cells and found that the protein was modified...

2011-04-04 19:52:37

As Parkinson's Awareness Month gets underway, a Canadian-led international study is providing important new insight into Parkinson's disease and paving the way for new avenues for clinical trials. The study, led by Dr. Michael Schlossmacher in Ottawa, provides the first link between the most common genetic risk factor for Parkinson's and the hallmark accumulation of a protein called alpha-synuclein within the brains of people with Parkinson's. It is published in the most recent edition of the...

2011-02-25 08:39:00

(Ivanhoe Newswire) -- What doctors initially say is Alzheimer's disease (AD), could actually turn out to be something else. New research shows that AD and other dementing illnesses may be easily misdiagnosed in the elderly. Over the last 30 years the number of people diagnosed with AD in the U.S. has skyrocketed. According to the CDC, AD affects an estimated five million Americans. But this study found that many of those patients could have been misdiagnosed. "Diagnosing specific dementias in...

2011-02-24 14:02:06

New research shows that Alzheimer's disease and other dementing illnesses may be easily misdiagnosed in the elderly, according to early results of a study of people in Hawaii who had their brains autopsied after death. The research is being released today and will be presented as part of a plenary session at the American Academy of Neurology's 63rd Annual Meeting in Honolulu April 9 to April 16, 2011. "Diagnosing specific dementias in people who are very old is complex, but with the large...

2010-11-03 16:18:35

A team of scientists from Japan and the University of California, San Diego School of Medicine have created a new mouse model that confirms that mutations of a protein called beta-synuclein promote neurodegeneration. The discovery creates a potential new target for developing treatments of diseases like Parkinson's and Alzheimer's. The work is published in today's issue of Nature Communications. Lead author is Makoto Hashimoto of the Division of Chemistry and Metabolism, Tokyo Metropolitan...

2010-10-15 16:40:32

Alzheimer's disease is not the only type of dementia. Two particular forms are dementia with Lewy bodies and Parkinson's disease dementia. In both forms, the diagnosis is of vital importance because the treatment for these dementias differs from that for Alzheimer's dementia, as Brit Mollenhauer and co-authors explain in the dementia theme issue of Deutsches Óžrzteblatt International (Dtsch Arztebl Int 2010; 107[39]: 684-91). In more than 75% of patients, the memory...

2010-10-14 05:00:00

PRINCETON, N.J., Oct. 14 /PRNewswire/ -- GE Healthcare, a unit of General Electric Company (NYSE: GE), today announced that DaTSCAN(TM) (ioflupane I 123 injection), a radiopharmaceutical agent intended for use with single photon emission computed tomography (SPECT) imaging of the brain, has been recommended in updated European Federation of the Neurological Societies (EFNS) guidelines for the diagnosis and management of Alzheimer's disease (AD). The guidelines appear in the October issue...

2010-09-16 08:10:00

(Ivanhoe Newswire) "“ Becoming forgetful may be more than just a function of old age. According to a new study, the same brain lesions that are associated with dementia are responsible for mild memory loss in old age. "It appears these brain lesions have a much greater impact on memory function in old age than we previously thought," study author Robert S. Wilson, PhD, at Rush University Medical Center in Chicago, was quoted as saying. "Our results challenge the concept of normal memory...


Word of the Day
snash
  • To talk saucily.
  • Insolent, opprobrious language; impertinent abuse.
This word is Scots in origin and probably imitative.