Quantcast
Last updated on April 20, 2014 at 19:30 EDT

Latest Li-Fraumeni syndrome Stories

2013-01-20 12:20:17

St. Jude Children's Research Hospital scientists lead a study that finds new genetic defects in high-risk childhood leukemia subtypes with chromosomal loss and evidence that some patients have an inherited cancer syndrome MEMPHIS, Tenn., Jan. 20, 2013 /PRNewswire-USNewswire/ -- Research led by St. Jude Children's Research Hospital scientists has identified a possible lead in treatment of two childhood leukemia subtypes known for their dramatic loss of chromosomes and poor treatment...

2012-06-29 06:25:40

Company Developing Diagnostic Tool for More Accurate Breast Cancer Staging NEW BRUNSWICK, N.J., June 29, 2012 /PRNewswire/ -- GeneAssess, Inc., a New Jersey-based biotechnology company, has received a commitment of up to $500,000 from Foundation Venture Capital Group (FVCG), Inc., to validate FRY, a cancer molecular signature gene discovered by GeneAssess scientists that could provide a more accurate diagnostic biomarker for cancer staging. According to James M. Golubieski, president of...

2011-12-15 17:39:01

Ohio State University researchers have discovered a hereditary cancer syndrome that predisposes certain people to a melanoma of the eye, along with lung cancer, brain cancer and possibly other types of cancer. The hereditary cancer syndrome is caused by an inherited mutation in a gene called BAP1, researchers say. The findings suggest that BAP1 mutations cause the disease in a small subset of patients with hereditary uveal melanoma and other cancers. Uveal melanoma is a cancer of the...

2011-12-03 11:08:04

MK 1775, a small, selective inhibitor molecule, has been found to be active against many sarcomas when tested by researchers at Moffitt Cancer Center in Tampa, Fla. Their findings, recently appearing in Molecular Cancer Therapeutics, published by the American Association for Cancer Research, suggest that a badly needed new agent against sarcomas - especially sarcomas affecting children - may be at hand. According to corresponding author Soner Altiok, M.D., Ph.D., sarcomas are rare forms of...

2011-12-01 10:47:45

Joslin study uncovers potential targets for treating disease Scientists at Joslin Diabetes Center in Boston have uncovered important molecular and genetic keys to the development of soft-tissue sarcomas in skeletal muscle, giving researchers and clinicians additional targets to stop the growth of these often deadly tumors. Published in the Proceedings of the National Academy of Sciences, the study identified two major molecular signaling pathways (the Ras and mTOR pathways) that are...

2011-09-25 12:05:00

REYKJAVIK, Iceland, September 25, 2011 /PRNewswire/ -- Scientists at deCODE Genetics and academic collaborators from Iceland, The Netherlands, Spain, Denmark, Germany, Sweden, the USA, the UK and Romania today report the discovery of a variant in the sequence of the human genome associated with risk of developing basal cell carcinoma of the skin (BCC), as well as prostate cancer and glioma, the most serious form of brain cancer. The study was done in collaboration with Illumina,...

2011-06-30 17:37:05

Discovery underscores how understanding the abnormalities that develop in the beginning stages of cancer can identify the root causes of the disease Zeroing in on the early cell mutations that enable a cancer to grow is one of the best ways to find a personalized therapy to stop it. Scientists were able to use a statistical approach for the first time to map out the order in which these abnormalities form to analyze the pattern of DNA changes in advanced skin and ovarian tumors. The study's...

5c61cbadf21ea0aff7788df0eb1b34c11
2008-03-19 10:09:56

Study suggests PET/CT may have value in screening Li-Fraumeni patientsResearchers at Dana-Farber Cancer Institute report that full-body PET/CT scanning detected unsuspected, treatable tumors in 3 of 15 patients with Li-Fraumeni syndrome (LFS), a rare genetic cancer syndrome for which no screening tests have been recommended.The results suggest that periodic scans in combination with physical exams might catch more tumors at a curable stage, the investigators report in the March 19 issue of...