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Latest Li-Huei Tsai Stories

2013-06-21 23:21:18

A study finds a possible link between a drug alternative that could slow age-associated impairments in the brain with restricting caloric intake. Prescopodene Nutritionals feels they can help reduce food consumption to extend brain functionality. Sydney, Australia (PRWEB) June 21, 2013 In an article on Science Daily's website, there has been evidence showing that restricting caloric intake can activate an enzyme called Sirtuin 1, or SIRT1, which may offer protection against...

2013-05-22 10:24:15

Animal study points to role of protein in anti-aging benefits of calorie restriction Activating an enzyme known to play a role in the anti-aging benefits of calorie restriction delays the loss of brain cells and preserves cognitive function in mice, according to a study published in the May 22 issue of The Journal of Neuroscience. The findings could one day guide researchers to discover drug alternatives that slow the progress of age-associated impairments in the brain. Previous studies...

2012-03-01 11:02:05

Neuroscientists show that HDAC2 enzyme could be a good target for new drugs MIT neuroscientists have shown that an enzyme overproduced in the brains of Alzheimer's patients creates a blockade that shuts off genes necessary to form new memories. Furthermore, by inhibiting that enzyme in mice, the researchers were able to reverse Alzheimer's symptoms. The finding suggests that drugs targeting the enzyme, known as HDAC2, could be a promising new approach to treating the disease, which...

2012-03-01 01:56:53

In a mouse model of Alzheimer's disease, memory problems stem from an overactive enzyme that shuts off genes related to neuron communication, a new study says. When researchers genetically blocked the enzyme, called HDAC2, they 'reawakened' some of the neurons and restored the animals' cognitive function. The results suggest that drugs that inhibit this particular enzyme would make good treatments for some of the most devastating effects of the incurable neurodegenerative disease. "It's...

2012-03-01 01:55:51

NIH-funded research could lead to new therapy A repression of gene activity in the brain appears to be an early event affecting people with Alzheimer's disease, researchers funded by the National Institutes of Health have found. In mouse models of Alzheimer's disease, this epigenetic blockade and its effects on memory were treatable. "These findings provide a glimpse of the brain shutting down the ability to form new memories gene by gene in Alzheimer's disease, and offer hope that we...

2011-11-17 10:57:59

Significant progress has been made in understanding the genetic risk factors underlying psychiatric disease. Recent studies have identified common genetic mutations conferring modest risk and rare variants comprising significant risk. One example of a rare cause of psychiatric disorders is the Disrupted in Schizophrenia-1 (DISC1) gene, first identified in a large Scottish pedigree displaying schizophrenia, bipolar disorder and depression. Common variants in DISC1 have been associated with...

2010-07-15 02:43:36

Scientists are making progress towards a better understanding of the neuropathology associated with debilitating psychiatric illnesses like bipolar disorder and schizophrenia. New research, published by Cell Press in the July 15 issue of the journal Neuron, reveals mechanisms that connect a known psychiatric risk gene to disruptions in brain cell proliferation and migration during development. A research group led by Dr. Li-Huei Tsai from the Massachusetts Institute of Technology had recently...

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2010-05-12 14:45:00

Findings could shed light on the evolution of human head size In work that may one day correct or prevent genetic conditions tied to smaller-than-normal brains and shed light on the evolution of human head size, researchers at MIT's Picower Institute for Learning and Memory analyzed the interaction of two proteins key to brain development. Neurogenesis is the process through which neurons are created during prenatal development to populate the growing brain. Li-Huei Tsai, director of the...

2009-04-27 08:46:20

Researchers use lasers to induce gamma brain waves in mice Scientists have studied high-frequency brain waves, known as gamma oscillations, for more than 50 years, believing them crucial to consciousness, attention, learning and memory. Now, for the first time, MIT researchers and colleagues have found a way to induce these waves by shining laser light directly onto the brains of mice. The work takes advantage of a newly developed technology known as optogenetics, which combines genetic...


Word of the Day
siliqua
  • A Roman unit of weight, 1⁄1728 of a pound.
  • A weight of four grains used in weighing gold and precious stones; a carat.
  • In anatomy, a formation suggesting a husk or pod.
  • The lowest unit in the Roman coinage, the twenty-fourth part of a solidus.
  • A coin of base silver of the Gothic and Lombard kings of Italy.
'Siliqua' comes from a Latin word meaning 'a pod.'
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