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Last updated on April 23, 2014 at 1:22 EDT

Latest Ligand Stories

2013-03-18 08:28:38

WELWYN GARDEN CITY, England and BOSTON, Massachusetts, March 18, 2013 /PRNewswire/ -- Scientific paper published in Molecular Pharmacology Heptares Therapeutics, the leading GPCR drug discovery and development company, announces the publication of a new paper describing how 'reverse pharmacology', enabled by its StaR(R) technology, can be applied to and accelerate GPCR-based drug discovery. The paper has been published in Molecular Pharmacology (ref. 1)...

2012-01-18 15:11:58

New Findings Could Influence Design of Future Diabetes Treatments Using a blend of technologies, scientists from the Florida campus of The Scripps Research Institute have painted a new picture of how biochemical information can be transmitted through the modification of a protein. Previously, scientists believed that during the pairing of proteins and their binding partners (“ligands”), proteins modified their shape while ligands remained stable. The new study shows this...

2012-01-10 23:40:04

New findings could influence design of future diabetes treatments Using a blend of technologies, scientists from the Florida campus of The Scripps Research Institute have painted a new picture of how biochemical information can be transmitted through the modification of a protein. Previously, scientists believed that during the pairing of proteins and their binding partners ("ligands"), proteins modified their shape while ligands remained stable. The new study shows this one-size-fits-all...

2011-11-04 21:02:48

Because the incidence of malignant melanoma is rising faster than any other cancer in the U.S., researchers at Moffitt Cancer Center in Tampa, Fla., and colleagues at Tampa-based Intezyne Technologies, Inc., Western Carolina University and the University of Arizona are working overtime to develop new technologies to aid in both malignant melanoma diagnosis and therapy. A tool of great promise comes from the world of nanomedicine - where tiny drug delivery systems are measured in the...

2011-10-03 13:22:38

New approach simplifies the search for more specific drugs Psychiatric ailments such as depression, obsessive-compulsive disorder or anxiety states are often associated with disturbances in the metabolism of the neurotransmitter serotonin. Neurotransmitters are compounds that are released from the synapses at nerve cell endings and activate the firing of neighboring neurons. Thus, as their name suggests, they mediate the transmission of nerve impulses. The serotonin transporter (SERT) is...

2011-09-06 22:51:08

Findings show how form controls function in sought-after therapeutic target In a joint study, scientists from the California and Florida campuses of The Scripps Research Institute have shown that changes in a protein's structure can change its signaling function and they have pinpointed the precise regions where those changes take place. The new findings could help provide a much clearer picture of potential drugs that would be both effective and highly specific in their biological...

2011-07-28 23:34:38

Research performed in Guy Bertrand's lab offers vast family of new catalysts for use in drug discovery, biotechnology Chemists at the University of California, Riverside have accomplished in the lab what until now was considered impossible: transform a family of compounds which are acids into bases. As our chemistry lab sessions have taught us, acids are substances that taste sour and react with metals and bases (bases are the chemical opposite of acids). For example, compounds of the element...

2011-04-11 15:37:56

Findings suggest new approach could create highly targeted therapeutics For years, scientists have thought of DNA as a passive blueprint capable only of producing specific proteins through RNA transcription. Now, research led by scientists from the Florida campus of The Scripps Research Institute has shown DNA can also act to fine-tune the activity of certain proteins known as nuclear receptors. These new findings may make it possible to design therapies that could activate specific genes in...

2010-11-19 13:41:28

Discovery could produce new approaches to treat numerous metabolic disorders Scientists from the Florida campus of The Scripps Research Institute have identified a novel synthetic activator of a pair of proteins that belong to a protein family playing key roles in human metabolism and immune function. The discovery could provide new and potentially more effective therapeutic approaches to diseases ranging from diabetes to osteoporosis. The study was published in the November issue (Volume 5,...

2010-10-11 14:06:39

Findings could transform drug development to produce more effective treatments Scientists from The Scripps Research Institute have uncovered new evidence that challenges the current theory about a process key to the way modern drugs are designed and how they work in the human body. The new study was published October 10, 2010 in an advance, online edition of the journal Nature Chemical Biology. Currently, the theory about ligands "“ compounds that bind to proteins and trigger a specific...