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Latest Lipid raft Stories

2013-09-23 14:00:33

Eukaryotic cells are compartmentalized by membranes, whose shape and dynamics are precisely regulated to maintain their correct functions. Consequently, many cellular processes such as endocytosis, migration and morphogenesis rely on proteins that bind directly to membranes and sculpt them into desired shapes. BAR domain proteins are among the central membrane-sculpting proteins in all eukaryote cells. Studies by Pekka Lappalainen laboratory at Institute of Biotechnology, University of...

2013-01-29 10:14:54

A new way of looking at a cell's surface reveals the distribution of small molecules in the cell membrane, changing the understanding of its organization. A novel imaging study by researchers from Lawrence Livermore National Laboratory, the University of Illinois and the National Institutes of Health revealed some unexpected relationships among molecules within cell membranes. Their findings provide a new way of studying cell structure and ultimately its function. Led by Mary Kraft...

2012-03-21 15:30:04

Why does inhaling anesthetics cause unconsciousness? New insights into this century-and-a-half-old question may spring from research performed at the National Institute of Standards and Technology (NIST). Scientists from NIST and the National Institutes of Health have found hints that anesthesia may affect the organization of fat molecules, or lipids, in a cell's outer membrane–potentially altering the ability to send signals along nerve cell membranes. "A better fundamental...

2011-10-10 09:11:11

Could controlling cell-membrane fat play a key role in turning off disease? Researchers at the University of Illinois at Chicago think so, and a biosensor they've created that measures membrane lipid levels may open up new pathways to disease treatment. Wonhwa Cho, distinguished professor of chemistry, and his coworkers engineered a way to modify proteins to fluoresce and act as sensors for lipid levels. Their findings are reported in Nature Chemistry, online on Oct. 9. "Lipid...

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2011-03-15 11:49:48

By David Salisbury, Vanderbilt University A new laser technique has demonstrated it can measure the interactions between proteins tangled in a cell's membrane and a variety of other biological molecules. These extremely difficult measurements can aid the process of drug discovery. Scientists estimate that about 30 percent of the 7,000 proteins in a human cell reside in the cell's membrane, and that these membrane proteins initiate 60 to 70 percent of the signals that control the operation of...

2010-07-22 15:35:39

A research team led by scientists at the Virginia Bioinformatics Institute (VBI) at Virginia Tech has discovered a fundamental entry mechanism that allows dangerous fungal microbes to infect plants and cause disease. The discovery paves the way for the development of new intervention strategies to protect plant, and even some animal cells, from deadly fungal infections. The findings are published in the July 23 edition of the journal Cell. The researchers have revealed how special...

2009-11-03 15:40:20

New research reveals how proteins that are critical for the transparency of the eye lens are properly sorted and localized in membrane bilayers. The study, published by Cell Press in the November 3rd issue of Biophysical Journal, analyzes how interactions between lipid and protein molecules can selectively concentrate proteins in certain regions of the cell membrane. All cells are surrounded by a dynamic semi-permeable structure called the plasma membrane. Cell plasma membranes are made of a...

2009-09-21 09:52:31

New data on signaling proteins, called G proteins, may prove important in fighting diseases such as cardiovascular, neurodegenerative disorders, and cancer. For many decades scientists have puzzled on "How signaling proteins transport and organize in specific areas of the cell?" Researchers from Nano-Science Center and Department of Neuroscience and Pharmacology provide yet unrecognized clues to solve this mystery. - We now begin to understand how signaling proteins recognize and transport to...

2008-08-22 03:00:15

By Anglin, Timothy C Conboy, John C ABSTRACT The dependence of 1,2-dipalmitoyl-sn-glycero-3- phosphocholine (DPPC) flip-flop kinetics on the lateral membrane pressure in a phospholipid bilayer was investigated by sum- frequency vibrational spectroscopy. Planar-supported lipid bilayers were prepared on fused silica supports using the Langmuir-Blodgett/ Langmuir-Schaeffer technique, which allows precise control over the lateral surface pressure and packing density of the membrane. The lipid...

2008-07-25 03:00:21

By Churchward, Matthew A Rogasevskaia, Tatiana; Brandman, David M; Khosravani, Houman; Nava, Phillip; Atkinson, Jeffrey K; Coorssen, Jens R ABSTRACT The Ca^sup 2+^-triggered merger of two apposed membranes is the defining step of regulated exocytosis. CHOL is required at critical levels in secretory vesicle membranes to enable efficient, native membrane fusion: CHOL-sphingomyelin enriched microdomains organize the site and regulate fusion efficiency, and CHOL directly supports the capacity...


Word of the Day
cruet
  • A vial or small glass bottle, especially one for holding vinegar, oil, etc.; a caster for liquids.
This word is Middle English in origin, and ultimately comes from the Old French, diminutive of 'crue,' flask.
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