Latest Lithium pharmacology Stories

2012-12-03 20:50:08

Down syndrome is a neurodevelopmental disorder that is the leading cause of genetically defined intellectual disability. In the brain, Down syndrome results in alterations in the connections between neurons and a reduction in the development of new neurons (neurogenesis) that usually occurs during learning. In this issue of the Journal of Clinical Investigation, researchers led by Laura Gasparini at the Istituto Italiano di Tecnologia in Genova, Italy report that lithium, a drug commonly used...

Bipolar Disorder Manic Gene Discovered
2012-09-02 07:47:48

redOrbit Staff & Wire Reports - Your Universe Online Researchers from the University of Bonn and the Central Institute of Mental Health (CIMH) in Mannheim claim to have discovered the gene responsible for causing the manic episodes associated with bipolar disorder. The scientists studied patient data and animal models, and were able to determine that the NCAN gene, which is believed to be involved in the modulation of cell adhesion and migration, is responsible for the restlessness,...

2012-03-13 23:34:00

Scientists have gained insight into why lithium salts are effective at treating bipolar disorder in what could lead to more targeted therapies with fewer side-effects. Bipolar disorder is characterised by alternating states of elevated mood, or mania, and depression. It affects between 1% and 3% of the general population. The extreme 'mood swings' in bipolar disorder have been strongly associated with disruptions in circadian rhythms — the 24-hourly rhythms controlled by our body...

2011-06-24 22:55:46

Buck Institute research in mice moves into preclinical stage; working toward human trials Lithium profoundly prevents the aggregation of toxic proteins and cell loss associated with Parkinson's disease (PD) in a mouse model of the condition. Preclinical research is now underway at the Buck Institute for Research on Aging to determine correct dosages for a drug that continues to be the gold standard for the treatment of bipolar disorder. The Buck is currently working toward initiating a Phase...

2009-05-01 11:00:00

A new study from Japan suggests that drinking water containing the element lithium may reduce the risk of suicide, BBC News reported. Lithium levels in drinking water and suicide rates were examined by researchers in the prefecture of Oita, which has a population of over one million residents. The team wrote in the British Journal of Psychiatry that the suicide rate was significantly lower in those areas that showed the highest levels of lithium. Doctors have long treated serious mood...

2009-04-21 11:43:08

Welsh researchers say they've discovered a possible mechanism that Lithium uses to combat bipolar disorders, suggesting more effective treatments. Lithium has been one of the most effective treatments for biopolar disorders for more than 50 years, yet scientists have never been entirely sure how it operates in the human brain. But now Cardiff University scientists say laboratory tests on cells have shown Lithium affects a molecule called PIP3 that is important in controlling brain-cell...

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