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Latest liver injury Stories

2013-11-11 13:14:01

More damage seen when FOXO3 suppressed, according to report in The American Journal of Pathology New data suggest that the transcription factor FOXO3 may protect against alcohol-induced liver injury. Researchers determined that alcohol given to mice deficient in FOXO3 caused severe liver injury resembling human alcoholic hepatitis. Further they found that although hepatitis C virus (HCV) and alcohol independently activated FOXO3, in combination they suppressed FOXO3, reduced expression of...

2013-06-26 20:40:43

More people are being affected by drug-induced liver injury (DILI) than ever before, according to a new study in Gastroenterology, the official journal of the American Gastroenterological Association. This type of liver injury results from the use of certain prescription and over-the-counter medications, as well as dietary supplements, and is among the more challenging forms of liver disease due to its difficulty to predict, diagnose and manage. Investigators conducted a population-based...

2012-05-22 21:20:11

New research being presented at Digestive Disease Week® (DDW) offers key insights into the progression of diseases leading to liver damage, which affect diverse populations, including young people. Studies show that the increasing rates of obesity are putting teens at risk for developing nonalcoholic fatty liver disease and are decreasing the availability of healthy livers for organ donations, which are urgently needed as people continue to experience complications from diseases, such as...

2011-03-04 14:18:00

Monthly liver enzyme testing is no longer required SILVER SPRING, Md., March 4, 2011 /PRNewswire-USNewswire/ -- The U.S. Food and Drug Administration today announced that monthly liver enzyme tests are no longer required for those taking Letairis tablets (ambrisentan), used to treat high blood pressure in the vessels that carry blood to the lungs (pulmonary arterial hypertension, or PAH). (Logo: http://photos.prnewswire.com/prnh/20090824/FDALOGO) Citing data from clinical trials and...

2010-11-30 21:36:52

Disproportionate number of women and minorities affected New research shows that anti-microbial medications are a common cause of drug-induced liver injury (DILI) leading to acute liver failure (ALF), with women and minorities disproportionately affected. While ALF evolves slowly, once it does occur a spontaneous recovery is unlikely; however liver transplantation offers an excellent survival rate. Full findings of this ten-year prospective study are published in the December issue of...

2009-09-02 07:30:00

PARSIPPANY, N.J., Sept. 2 /PRNewswire/ -- The following is an updated GlaxoSmithKline Consumer Healthcare statement in response to the FDA's Early Communication about the safety review of orlistat: On August 24th the FDA reported that it is continuing its safety review of orlistat and liver-related serious adverse events. To view the Multimedia News Release, go to: http://www.prnewswire.com/mnr/alli/39949/ It's important consumers know that alli is safe and effective and there's no...

2009-06-03 13:05:33

The U.S. Food and Drug Administration warned health care professionals Wednesday of the risk of serious liver injury from the use of an anti-thyroid drug. After analyzing adverse event reports, the FDA has identified an increased risk of liver injury with propylthiouracil (commonly known as PTU) when compared to an alternative treatment for Graves' disease, methimazole, Dr. Amy Egan of the FDA's Center for Drug Evaluation and Research said. Health care professionals should carefully consider...

2009-06-01 07:14:22

 The International Serious Adverse Events Consortium (SAEC) announced today initial results from its research designed to discover genetic markers that may predict individuals at risk for serious drug induced liver injury (DILI). The SAEC is a nonprofit research corporation, launched in the fall of 2007, comprised of and funded by 10 leading pharmaceutical companies and the Wellcome Trust. The U.S. Food and Drug Administration (FDA) also contributes to the scientific and strategic...

2009-04-17 13:46:56

Kupffer cells, resident tissue macrophages that line the liver sinusoids, play a key role in modulating inflammation in a number of experimental models of liver injury. Since Kupffer cells represent only a small portion of the entire liver cell population, greatly outnumbered by the parenchymal cells, Kupffer cell isolation faces major technical obstacles. Laser capture microdissection (LCM) offers a method of isolating a single cell type from specific regions of tissue sections. A research...

2005-07-18 19:03:09

Drug-induced liver disease (DILD), a potential complication seen with some medications, is usually not life-threatening, but may occasionally be more severe with a high mortality, requiring a liver transplant in selected cases. During the last decade, drug-induced liver injury has led to the withdrawal of a number of drugs from the market. Hy's rule, an observation by the late Dr. Hyman Zimmerman, states that the combination of high liver cell damage as measured by liver enzymes and jaundice...


Word of the Day
omadhaun
  • A fool; a simpleton: a term of abuse common in Ireland and to a less extent in the Gaelic-speaking parts of Scotland.
This word is partly Irish in origin.