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Latest Liver X receptor Stories

Macular Degeneration May One Day Be Treated With Cholesterol Lowering Eye Drops
2013-04-03 05:42:13

[ Watch the Video: Cholesterol-Lowering Eye Drops Could Treat Macular Degeneration ] redOrbit Staff & Wire Reports - Your Universe Online Macular degeneration, the leading cause of blindness in Americans over the age of 50, could be treated using medications traditionally used to lower cholesterol levels, researchers from the Washington University School of Medicine in St. Louis claim in a new study. The investigators, who detailed their findings online in the journal Cell...

2011-08-04 12:30:00

SAN DIEGO, Aug. 4, 2011 /PRNewswire/ -- Johnson & Johnson Pharmaceutical Research & Development, L.L.C. (J&JPRD) announced today the publication of research that uncovered a previously unknown role for a class of molecules that could lead to future advances in immunologic medicine. The findings show a definitive link between EBI2, a G-protein-coupled receptor that controls B-cell migration, and some unexpected immunological effects of certain oxysterols. Co-authored by the...

2011-03-31 00:56:10

UCLA researchers have demonstrated that a key regulator of cholesterol and fat metabolism in the liver also plays an important role in the development of liver fibrosis "” the build-up of collagen scar tissue that can develop into cirrhosis. Cirrhosis, in turn, is a major cause of premature death and is incurable without a liver transplant. Published in the March issue of the journal Gastroenterology, the study shows that liver X receptors (LXRs), master regulators of cholesterol, fat...

2010-12-01 22:33:37

Glucocorticoid drugs are used widely to treat numerous conditions, including rheumatoid arthritis, allergic reactions, asthma, and some forms of cancer, and transplant recipients. The beneficial effects of these drugs are their potent antiinflammatory and immunosuppressive properties. However, their long-term use is limited by severe side effects, including high blood levels of glucose, fatty liver, and type 2 diabetes. A team of researchers, led by Carolyn Cummins, at the University of...

2010-11-15 20:30:13

Specific, relatively uncommon variations at a region of human chromosome 8 have recently been linked to fat (lipid) levels in the blood that decrease an individual's risk of atherosclerosis (a disease of the major arterial blood vessels that is a main cause of heart attack and stroke). The only currently described gene in this region of chromosome 8 is TRIB1, but it has not been previously linked in any way to regulation of lipid levels. Now, a team of researchers, led by Jan Breslow, at The...

2010-06-25 15:55:26

Jan-Ó¦ke Gustafsson investigates 'wireless connections' in the brain Many diseases of brain function, such as epilepsy and schizophrenia, are caused by problems in how neurons communicate with each other. A University of Houston (UH) researcher and his team are analyzing these commands and connections in an attempt to prevent those diseases. Dr. Jan-Ó¦ke Gustafsson, Robert A. Welch Professor in UH's biology and biochemistry department,...

2009-12-02 18:26:55

Tiny insects can shed light on human regulatory processes, U of U-led studies find How do fruit flies get high cholesterol and become obese? The same way as people do "“ by eating a diet that's too rich in fats. More importantly, according to two new studies led by a University of Utah human geneticist, fruit flies use the same molecular mechanisms as humans to help maintain proper balances of cholesterol and a key form of stored fat that contributes to obesity. The findings mean that...

2009-07-21 08:09:44

A UCLA study has identified a way to turn off a key signaling pathway involved in physiological processes that can also stimulate the development of cancer and other diseases. The findings may lead to new treatments and targeted drugs using this approach. In the study, which is currently available in the online edition of the journal Molecular Endocrinology, scientists found that by activating a receptor in cells called the liver X receptor (LXR), they were able to inhibit the hedgehog (Hh)...

2009-02-16 13:27:42

Researchers in Austria have developed and tested a synthetic atherosclerosis drug that can reduce the buildup of dangerous blood vessel plaques. First author Adelheid Kratzer of the University of Graz said the encouraging results of this study in mice could lead to a new type of drug to treat or even prevent atherosclerosis without producing the side effect of fatty liver disease, which leads to its own set of problems such as diabetes. The drug, DMHCA, targets proteins called the Liver X...

2008-11-06 06:00:21

Exelixis, Inc. (Nasdaq:EXEL) today announced that it has signed an extension of the company's research collaboration agreement with Bristol-Myers Squibb Company (NYSE:BMY) to discover novel therapies targeted against the Liver X Receptor (LXR), a nuclear hormone receptor implicated in a variety of cardiovascular and metabolic disorders. The collaboration, originally established in January of 2006 for a period of two years, was extended in 2007, at Bristol-Myers Squibb's request, through...


Word of the Day
vermicular
  • Like a worm in form or movement; vermiform; tortuous or sinuous; also, writhing or wriggling.
  • Like the track or trace of a worm; appearing as if worm-eaten; vermiculate.
  • Marked with fine, close-set, wavy or tortuous lines of color; vermiculated.
  • A form of rusticated masonry which is so wrought as to appear thickly indented with worm-tracks.
This word ultimately comes from the Latin 'vermis,' worm.
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