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Latest Long noncoding RNA Stories

2012-06-20 06:21:34

(Ivanhoe Newswire) — A new study opens doors to understanding prostate cancer with the identification of a potential new pathway in prostate cancer cells by which cancer-driving gene products can be created. "Our work shows that cancers have many more tricks than we thought to generate potential cancer-driving genes or gene products," Hui Li, Ph.D., assistant professor of pathology at the University of Virginia in Charlottesville, and a recipient of an Innovative Research Grant from...

2012-06-19 14:07:28

Researchers have identified a potential new pathway in prostate cancer cells by which cancer-driving gene products can be generated, according to a study published in Cancer Discovery, a journal of the American Association for Cancer Research. "Our work shows that cancers have many more tricks than we thought to generate potential cancer-driving genes or gene products," said Hui Li, Ph.D., assistant professor of pathology at the University of Virginia in Charlottesville, and a recipient of...

2012-05-11 14:20:22

Melanoma is the most deadly form of skin cancer, estimated by the National Cancer Institute to afflict more than 70,000 people in the United States annually and the incidence rate continues to rise. In a study published online in Genome Research (www.genome.org), researchers have identified a previously unknown non-coding RNA that plays an important role in the biology of melanoma, a finding that could lead to a new target for therapy. Most skin cancers are nonmelanomas, arising from cells...

2011-12-22 15:38:48

FINDINGS: Whitehead Institute scientists have identified conserved, long intervening non-coding RNAs (lincRNAs) that play key roles during brain development in zebrafish, and went on to show that the human versions of these RNAs can substitute for the zebrafish lincRNAs. RELEVANCE: Despite their prevalence in the cell, lincRNAs have been referred to as the "dark matter" of all the transcribed RNAs because little is known of their functions or mechanisms. Until now, lincRNAs have been...

2011-12-08 13:39:57

FINDINGS: A long non-coding RNA (lncRNA) prevents programmed cell death during one of the final stages of red blood cell differentiation, according to Whitehead Institute researchers. This is the first time a lncRNA has been found to play a role in red blood cell development and the first time a lncRNA has been shown to affect programmed cell death. RELEVANCE: Programmed cell death, or apoptosis, occurs in many cell development pathways; preventing normal cell death is a key step in the...

2011-11-10 18:35:59

Cells develop and thrive by turning genes on and off as needed in a precise pattern, a process known as regulated gene transcription. In a paper published in the Nov. 9 issue of the Journal of Neuroscience, researchers at the University of California, San Diego School of Medicine say this process is even more complex than previously thought, with regulated genes actually relocated to other, more conducive places in the cell nucleus. "When regulated gene transcription goes awry, many human...

2011-09-29 23:01:17

A new technique developed by researchers at the Stanford University School of Medicine allows researchers to identify the exact DNA sequences and locations bound by regulatory RNAs. This information is necessary to understand how the recently identified RNA molecules control the expression of neighboring and distant genes. The study offers a startling glimpse into the intricate world of gene expression and how RNA, once thought to be only a lowly cellular messenger, actively unlocks our...

2011-08-29 12:11:44

Global view of 'lincRNAs' reveals critical role in regulation of embryonic stem cells Scientists at the Broad Institute of MIT and Harvard have discovered that a mysterious class of large RNAs plays a central role in embryonic development, contrary to the dogma that proteins alone are the master regulators of this process. The research, published online August 28 in the journal Nature, reveals that these RNAs orchestrate the fate of embryonic stem (ES) cells by keeping them in their...

2011-05-11 00:28:41

Long non-coding RNA promotes melanoma cell survival and invasion -- providing a potential new diagnostic marker for skin cancer Traditionally, RNA was mostly known as the messenger molecule that carries protein-making instructions from a cell's nucleus to the cytoplasm. But scientists now estimate that approximately 97 percent of human RNA doesn't actually code for proteins at all. A flurry of research in the past decade has revealed that some types of non-coding RNAs switch genes on and off...

2011-05-09 13:09:03

Over the past decades, researchers seeking to understand molecular mechanisms underlying various diseases, notably cancer, have taken advantage of DNA microarrays to interrogate tissues specimen of patients for the expression status of thousands of genes at once. Jointly, such gene expression status of each gene in the genome, measured as the level of their transcripts, constitutes the gene expression profile. Since each of the tens of thousands of genes can be switched on or off, a gene...


Word of the Day
glogg
  • Scandinavian punch made of claret and aquavit with spices and raisins and orange peel and sugar.
This word comes from the Swedish 'glogg,' which is an alteration of 'glodgat,' mulled (wine).
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