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Latest Long-term potentiation Stories

2009-11-12 12:34:32

Short-term memory may depend in a surprising way on the ability of newly formed neurons to erase older connections. That's the conclusion of a report in the November 13th issue of the journal Cell, a Cell Press publication, that provides some of the first evidence in mice and rats that new neurons sprouted in the hippocampus cause the decay of short-term fear memories in that brain region, without an overall memory loss. The researchers led by Kaoru Inokuchi of The University of Toyama in...

2009-09-08 07:54:55

Researchers discover that the addition of the phosphor molecule to a the NMDA receptor in the brain is a necessary step in memory formation A new study that was carried out at the University of Haifa has identified another component in the chain of actions that take place in the neurons in the process of forming memories. This discovery joins a line of findings from previous studies that together provide a better understanding of the most complex processes in nature "“ the process of...

2009-09-02 14:21:59

U.S. scientists say they have discovered rats engage in a mental re-enactment of their recent experiences when choosing what actions to take. Massachusetts Institute of Technology researchers said they recorded the activity of single neurons called place cells in a brain structure -- the hippocampus -- that has been shown to be crucial for learning and memory. They found place cells are activated in a unique pattern and sequence for each specific location in a maze. When examining the brain...

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2009-07-13 10:55:00

New study helps explain why it is easy to encode new memories but hard to hold onto themMemories aren't made of actin filaments. But their assembly is crucial for long-term potentiation (LTP), an increase in synapse sensitivity that researchers think helps to lay down memories. In the July 13, 2009 issue of the Journal of Cell Biology (www.jcb.org), Rex et al. reveal that LTP's actin reorganization occurs in two stages that are controlled by different pathways, a discovery that helps explain...

2009-06-24 12:07:23

Scientists have uncovered a novel mechanism linking soluble amyloid ? protein with the synaptic injury and memory loss associated with Alzheimer's disease (AD). The research, published by Cell Press in the June 25 issue of the journal Neuron, provides critical new insight into disease pathogenesis and reveals signaling molecules that may serve as potential additional therapeutic targets for AD.Amyloid ? protein (A?) plays a major pathogenic role in AD, a devastating neurodegenerative disorder...

2009-05-18 15:42:01

The instruction manual for maintaining an efficient brain may soon include a section on synaptotagmin-IV (Syt-IV), a protein known to influence learning and memory, thanks to a study by University of Wisconsin-Madison researchers.The study showed that Syt-IV keeps the strength of synapses "” connections between nerve cells where communication occurs "” within a useful range of neither too strong nor too weak.Synapses' ability to adjust over time by becoming bigger and stronger or...

2009-05-05 13:26:23

U.S. scientists say they are the first to find a form of synaptic memory in the olfactory bulb -- the part of the brain that processes the sense of smell. Case Western Reserve University Associate Professor Ben Strowbridge and doctoral student Yuan Gao noted that during the 1970s, scientists discovered synapses could change their strength following brief periods of activity. That process, called long-term potentiation, is the leading candidate to explain how we store information about...

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2008-08-02 11:45:00

New research has uncovered a fundamental cellular mechanism that may drive pathological drug-seeking behavior. The study, published by Cell Press in the July 31 issue of the journal Neuron, examines the brain's reward circuitry and details strikingly distinct influences of self-administered cocaine compared to natural rewards or passive cocaine injection. Dopamine (DA) neurons residing within the ventral tegmental area (VTA) of the brain are a key part of the brain's natural reward pathway...

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2008-06-19 12:14:11

UCLA cellular neuroscientists are providing new insights into the mechanisms that underlie long-term memory "” research with the potential to treat long-term memory disorders. "The more we know about how long-term memory is induced in the brain and how our memories are maintained in the brain, the more we are going to be able to treat long-term memory loss," said David Glanzman, UCLA professor of physiological science and neurobiology, whose new research appears June 19 in the early...

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2008-01-21 10:30:14

MADISON "“ Most people know it from experience: After so many hours of being awake, your brain feels unable to absorb any more -- and several hours of sleep will refresh it. Now new research from the University of Wisconsin School of Medicine and Public Health clarifies this phenomenon, supporting the idea that sleep plays a critical role in the brain's ability to change in response to its environment. This ability, called plasticity, is at the heart of learning. Reporting in the Jan....